Self Assembly Methods for Surface Properties for stents

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2004
Program:
SBIR
Phase:
Phase I
Contract:
1R43HL075962-01
Award Id:
70932
Agency Tracking Number:
HL075962
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
NANOSONIC, INC., 1485 S MAIN ST, BLACKSBURG, VA, 24060
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JENNIFER HOYTLALLI
(540) 953-1785
JLALLI@NONOSONIC.COM
Business Contact:
RICHARD CLUAS
(540) 953-1785
ROCLAUS@NANOSONIC.COM
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): The research outlined in this proposal is based on the observation that stent failure is due, in part, to acute thrombus accumulation combined with chronic hemodynamic and solid mechanical stress created by these devices within the host vessel. The proposed SBIR research program would test a working hypothesis in order to elucidate the relationship between acute thrombus accumulation and remodeling of the vessel. The hypothesis is that compliance mismatched stents create adverse stresses within the host vessel that promote tissue proliferation, and that this stress can be minimized with specific design improvements, specifically by matching or grading the mechanical compliance between the stent metal and the host tissue. This hypothesis would be tested during Phase I and during Phase II. The specific aims of the total SBIR program research are: 1. To analyze the fluid and solid mechanical stress created by compliance mismatched and compliance matched stents using experimental and computational methods in realistic arterial models. 2. To design and manufacture a structurally optimized compliance-matched coated stent based on this analysis. 3. To evaluate the in vivo performance of the optimized compliance-matched stent design in a swine model(presently funded by AHA). Specifically, NanoSonic would work with the Wake Forest University Medical Center to design, fabricate and evaluate stents coated with compliance-matched and compliance-graded mechanical coatings formed using molecular level layer-by-layer nanoassembly synthesis processes. These patented nanotechnology-based processes would allow the spatial grading of mechanical and other properties at the molecular level, specifically as required by our working hypothesis, to mitigate turbulent flow-induced restenosis.

* information listed above is at the time of submission.

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