ANTITUMOR AGENTS FROM NATURAL SOURCES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4811
Agency Tracking Number:
4811
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
345 Georgetown Square, Suite 201, Wood Dale, IL, 60191
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
CHUN-TAO CHE
PRINCIPAL INVESTIGATOR
(312) 766-6204
Business Contact:
() -
Research Institute:
n/a
Abstract
PLANTS AND OTHER LIVING ORGANISMS REPRESENT VALUABLE STARTING MATERIALS FOR THE ISOLATION OF CLINICALLY EFFICACIOUS ANTICANCER AGENTS. THE MECHANISM OF ACTION OF NEARLY ALL ANTICANCER AGENTS INVOLVES DISRUPTING THE NORMAL PHYSIOLOGICAL FUNCTION OF DNA, AND MANY AGENTS ACT BY DIRECTINTERACTION. THUS, BY UTILIZING THIS KNOWN TARGET MACRO- MOLECULE, NAPROTECH CURRENTLY PROPOSES TO DEVISE METHODS FORTHE DETECTION AND PROCUREMENT OF POTENTIAL ANTITUMOR AGENTS THAT FUNCTION BY THIS PARTICULAR MECHANISM OF ACTION. IN PRELIMINARY STUDIES IT HAS BEEN ESTABLISHED THAT HPLC METHODOLOGY CAN BE EMPLOYED TO DETECT SUBSTANCES IN CRUDE PLANT EXTRACTS THAT ARE CAPABLE OF BINDING TO DNA. A GOOD CORRELATION WITH CYTOTOXIC POTENTIAL WAS ALSO FOUND. WITH THESE AND OTHER PLANT EXTRACTS OR PURE COMPOUNDS, PHASE I STUDIES WILL BE PERFORMED TO ESTABLISH THE GENERAL UTILITY OF THIS PROCEDURE FOR USE AS A PRESCREEN OR A METHOD FOR DETECTING BINDING COMPONENTS IN FRACTIONS OBTAINED DURING PURIFICATION SCHEMES. PROCEDURES WILL ALSO BE ATTEMPTED TO ESTABLISH THE FEASIBILITY OF BIOSPECIFICALLY EXTRACTING BINDING COMPONENTS FROM CRUDE MIXTURES ON THE BASIS OF DNA AFFINITY. EXPERIMENTS WILL BE PERFORMED UTILIZING DNA COUPLED TO CELLULOSE AND EQUILIBRIUM DIALYSIS. QUANTITATIVEASPECTS AND THE ABILITY TO RECOVER BOUND SUBSTANCES WILL BE STUDIED. SUCCESS IN THESE AREAS COULD ULTIMATELY LEAD TO SUBSTANTIAL SAVINGS IN TIME AND EFFORT, AND THE RAPID PROCUREMENT OF NOVEL CYTOTOXIC OR ANTITUMOR AGENTS FROM NATURAL SOURCES.

* information listed above is at the time of submission.

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