IDENTIFICATION OF NOVEL TOPOISOMERASE INHIBITORS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$48,675.00
Award Year:
1989
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
11158
Agency Tracking Number:
11158
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
175 5th Ave #1101, New York, NY, 10010
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
PLANT EXTRACTS AND TRADITIONAL MEDICINES HAVE LONG BEEN THOUGHT TO CONTAIN BIOACTIVE MOLECULES CAPABLE OF ELICITING A THERAPEUTIC RESPONSE. HOWEVER, THE POTENTIAL UTILITY OR MODE OF ACTION OF THESE NATURAL PRODUCTS HAS NOT BEEN EFFECTIVELY STUDIED IN WESTERN SCIENTIFIC RESEARCH. RECENT ADVANCES IN THE MOLECULAR UNDERSTANDING OF DRUG ACTION WILL BE EMPLOYED IN PHASE I IN AN EFFORT TO IDENTIFY AND FURTHER EVALUATE THE BIOACTIVITY OF NATURAL PRODUCTS. PLANT EXTRACTS AND TRADITIONAL MEDICINES WILL BE ANALYZED IN A HIGH-THROUGHPUT BIOCHEMICAL ASSAY FOR THEIR ABILITY TO INHIBIT TOPOISOMERASE ACTIVITY IN TRANSFORMED CELL LINES. BECAUSE TOPOISOMERASES HAVE BEEN IDENTIFIED AS THE PRIMARY TARGET OF SOME OF THE MOST POPULAR ANTINEOPLASTIC DRUGS CURRENTLY IN USE, THIS ASSAY WOULD IDENTIFY NATURAL PRODUCTSTHAT WOULD ULTIMATELY BE DEVELOPED INTO NOVEL ANTICANCER AGENTS. THE ABILITY OF LEAD COMPOUNDS TO INHIBIT TOPOISOMERASE ACTIVITY IN VITRO USING PURIFIED TOPOISOMERASE I AND II, AS WELL AS THEIR ABILITY TO INHIBIT THE GROWTH IN TRANSFORMED CELLS IN VITRO, WILL ALSO BE EVALUATED. PROMISING LEAD COMPOUNDS WOULD BE FURTHER PURIFIED AND DEVELOPED AS ANTICANCER AGENTS IN PHASE II.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government