COMPONENTS OF PARASITIC WASP VENOMS USEFUL FOR CONTROL OF INSECT PESTS

Award Information
Agency:
Department of Agriculture
Branch
n/a
Amount:
$240,000.00
Award Year:
1993
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
18863
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Natural Product Science Inc.
420 Chipeta Way Suite 240, Salt Lake City, UT, 84108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Forrest H Fuller
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
WE PROPOSE A PHASE I PROGRAM TO EVALUATE THE INSECTICIDAL PROPERTIES AND COMPONENTS OF CERTAIN PARASITIC WASP VENOMS. MOST INSECTS, INCLUDING MOST IMPORTANT CROP PESTS. ARE ATTACKED BY ONE OR MORE SPECIES OF PARASITIC WASPS. THE VENOMS OF PARASITIC WASPS ARE KNOWN TO HAVE A WIDE RANGE OF EFFECTS ON THEIR HOSTS, INCLUDING PARALYSIS, GROWTH REGULATION, AND SUPPRESSION OF THE IMMUNE SYSTEM. THE BASE BIOLOGICAL AND PHYSIOLOGICAL DIVERSITY OF PARASITIC WASPS SUGGESTS THAT THEIR VENOMS ARE A POTENTIALLY RICH SOURCE OF POTENT, SELECTIVE, INSECTICIDAL TOXINS WITH NOVEL, USEFUL CHEMISTRIES AND MODES OF ACTION. SUCH TOXINS MAY BE EXPECTED TO SERVE AS LEADS FOR DEVELOPING NEW CLASSES OF SYNTHETIC CHEMICAL INSECTICIDES AND AS THE BASIS FOR RECOMBINANT BIOPESTICIDES. ALTHOUGH AVAILABLE DATA ARE LIMITED, THEY SUGGEST THAT THESE VENOMS MAY PROVIDE THE MOST POTENT INSECT-SPECIFIC TOXINS IDENTIFIED TO DATE. WE HAVE PREPARED A LIST OF TAXONOMICALLY DIVERSE SPECIES, THE VENOMS OF WHICH ARE LIKELY TO CONTAIN PARALYTIC ACTIVITIES. IN PHASE I, VENOM GLAND OR WHOLE WASP EXTRACTS WILL BE SURVEYED FOR INCAPACITATING ACTIVITIES AGAINST IMPORTANT LEPIDOPTERAN CROP PEST. THE BIOLOGICAL AND PHYSICAL PROPERTIES OF THE MOST EFFECTIVE ACTIVITIES WILL BE FURTHER CHARACTERIZED. BASED ON THESE RESULTS, PURIFICATION OF THE MOST EFFECTIVE TOXINS WILL BE INITIATED.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government