THE PURPOSE OF THIS PROJECT IS TO LABEL MONOCLONAL ANTIBODIES WITH ASTATINE-211 FOR USE IN RADIO-IMMUNOTHERAPY.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
4812
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Neorx Corp
410 West Harrison Street, Seattle, WA, 98119
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
D SCOTT WILBUR
PRINCIPAL INVESTIGATOR
(206) 281-7001
Business Contact:
() -
Research Institution:
n/a
Abstract
THE PURPOSE OF THIS PROJECT IS TO LABEL MONOCLONAL ANTIBODIES WITH ASTATINE-211 FOR USE IN RADIO-IMMUNOTHERAPY.THE GOAL OF THE PROPOSED RESEARCH IS TO DEVELOP A METHOD TO INCORPORATE ASTATINE INTO ANTIBODIES SUCH THAT THE ASTATINE LABILE IN VITRO OR IN VIVO. IN THE INVESTIGATION, TWO DIFFERENT APPROACHES TO LABELING WILL BE COMPARED. ONE APPROACH WILL BE DIRECT LABELING WITH ASTATINE; THE OTHER APPROACH WILL INVOLVE THE USE OF ASTATINATED SMALL MOLECULES. THE LATTER APPROACH WILL INCLUDE DEVELOPMENT OF METHODS TO FIRMLY ATTACH THE ASTATINE TO THE SMALL MOLECULES.

* information listed above is at the time of submission.

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