THE OBJECTIVE OF THIS PHASE I PROJECT IS TO DEVELOP AND EVALUATE A NOVEL METHOD FOR RADIOLABELING MONOCLONAL ANTI- BODIES WITH TECHNETIUM-99M FOR THE SPECIFIC DIAGNOSIS OF CANCER.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4814
Agency Tracking Number:
4814
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Neorx Corp (Currently NEORX CORPORATION)
410 West Harrison Street, Seattle, WA, 98119
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JOHN M RENO
PRINCIPAL INVESTIGATOR
(206) 281-7001
Business Contact:
() -
Research Institution:
n/a
Abstract
THE OBJECTIVE OF THIS PHASE I PROJECT IS TO DEVELOP AND EVALUATE A NOVEL METHOD FOR RADIOLABELING MONOCLONAL ANTI- BODIES WITH TECHNETIUM-99M FOR THE SPECIFIC DIAGNOSIS OF CANCER. THE METHOD PROVIDES FOR A VERY EFFICIENT UPTAKE OF OFFERED TECHNETIUM TO THE HIGH SPECIFIC ACTIVITY REQUIRED FOR RADIOIMAGING. ANTIBODY PREPARED ACCORDING TO THE DESCRIBED METHOD RETAINS MOST OF ITS IMMUNOREACTIVITY, AND NO DETECTABLE DENATURATION OR AGGREGATION IS OBSERVED. STABILITY OF THE PREPARED ANTIBODY IS POOR, HOWEVER; THE ANTIBODY LOSES ITS ABILITY TO COMPLEX TECHNETIUM WITHIN 24 HOURS. THIS PROPOSAL DETAILS TWO POTENTIAL METHODS FOR GAINING THE REQUIRED STABILITY FOR RADIOPHARMACEUTICAL KIT FORMULATION. FURTHER, THE PROPOSAL PROVIDES FOR A THOROUGH EVALUATION OF THE TECHNETIUM LABELED ANTIBODY WITH IN VITRO METHODS AND IN VIVO WITH HUMAN TUMOR XENOGRAPHS IN MICE AND RATS. IF PHASE I EFFICACY CAN BE DEMONSTRATED IN THE ANIMALTUMOR MODELS, THIS WILL SET THE STAGE FOR HUMAN CLINICAL TRIALS TO BE CARRIED OUT IN A PHASE II STUDY.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government