NON-INVASIVE BORON IMAGING IN HUMAN BRAIN WITH MRI

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1993
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
19374
Agency Tracking Number:
19374
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
50 North Medical Drive, Ac-213, Salt Lake City, UT, 84132
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Kenneth M Bradshaw
(801) 581-7027
Business Contact:
() -
Research Institution:
n/a
Abstract
BORON NEUTRON CAPTURE THERAPY (BNCT) OPTIMIZATION REQUIRES KNOWLEDGE OF TUMOR-BORON UPTAKE AND ELIMINATION KINETICS AND CONCENTRATIONS. AT PRESENT, THIS KNOWLEDGE IS OBTAINED THROUGH INVASIVE METHODS. THROUGH A NONINVASIVE METHOD, MULTIPLE DATA POINTS CAN BE OBTAINED OVER TIME WITHOUT DISTURBING THE BIOLOGICAL ENVIRONMENT. INITIAL STUDIES HAVE SHOWN THAT MAGNETIC RESONANCE IMAGING (MRI) CAN BE USED AS A NONINVASIVE TOOL TO DETERMINE BORON CONCENTRATION AS A FUNCTION OF TIME AND LOCATION. WE WILL DEVELOP A NEW NONINVASIVE TECHNIQUE USING BORON MRI FOR THE PURPOSE OF IMPROVING THE RESEARCHER'S ABILITY TO CONDUCT BORON PHARMACOKINETIC STUDIES.

* information listed above is at the time of submission.

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