NON-INVASIVE BORON IMAGING IN HUMAN BRAIN WITH MRI

Award Information
Agency:
Department of Health and Human Services
Amount:
$500,000.00
Program:
SBIR
Contract:
N/A
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
1993
Phase:
Phase II
Agency Tracking Number:
19374
Solicitation Topic Code:
N/A
Small Business Information
Neutron Technology
50 North Medical Drive, Ac-213, Salt Lake City, UT, 84132
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Kenneth M Bradshaw
 (801) 581-7027
Business Contact
Phone: () -
Research Institution
N/A
Abstract
BORON NEUTRON CAPTURE THERAPY (BNCT) OPTIMIZATION REQUIRES KNOWLEDGE OF TUMOR-BORON UPTAKE AND ELIMINATION KINETICS AND CONCENTRATIONS. AT PRESENT, THIS KNOWLEDGE IS OBTAINED THROUGH INVASIVE METHODS. THROUGH A NONINVASIVE METHOD, MULTIPLE DATA POINTS CAN BE OBTAINED OVER TIME WITHOUT DISTURBING THE BIOLOGICAL ENVIRONMENT. INITIAL STUDIES HAVE SHOWN THAT MAGNETIC RESONANCE IMAGING (MRI) CAN BE USED AS A NONINVASIVE TOOL TO DETERMINE BORON CONCENTRATION AS A FUNCTION OF TIME AND LOCATION. WE WILL DEVELOP A NEW NONINVASIVE TECHNIQUE USING BORON MRI FOR THE PURPOSE OF IMPROVING THE RESEARCHER'S ABILITY TO CONDUCT BORON PHARMACOKINETIC STUDIES.

* information listed above is at the time of submission.

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