Local Hyperthermia Catheter for Enhanced Ablation and Cancer Therapy

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$151,128.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA150310-01
Award Id:
95904
Agency Tracking Number:
CA150310
Solicitation Year:
n/a
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
BIOTEX, INC., 8058 EL RIO ST, HOUSTON, TX, 77054
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
969792050
Principal Investigator:
ASHOK GOWDA
(713) 741-0111
ASHOK@BIOTEXMEDICAL.COM
Business Contact:
ASHOK GOWDA
() -
ashok@biotexmedical.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): The goal of this Phase I SBIR Grant Proposal is to develop a new device and methodology for local elevation of a target tissue's temperature prior to a planned thermal ablation, a process we've dubbed hyperablation . I n preliminary work we demonstrated that raising the pre-treated temperature of a target tissue by 100C resulted in a 60% increase in volumetric ablation size. Others have shown the benefits of embolization or other methods to decrease convective cooling fr om blood flow prior to an ablation procedure. The proposed hyperablation device would provide a unique way to accomplish both strategies and should lead to a significant increase in thermal ablation efficiency. Application of this technology may go beyond ablation and prove useful in a number of areas where hyperthermia is being investigated such as heat- activated liposomal chemotherapy, regional chemotherapy, and hyperthermia-enhanced radiation procedures. We will seek input from clinical collaborators a nd perform modeling simulations to guide the design of the hyperthermia catheter. We will source materials, fabricate prototypes, and test the device in a benchtop setup using physiologic conditions and tissue samples. Finally, we will work with clinical e xperts in interventional radiology to test the device in a large animal model and evaluate the performance and potential benefits of this treatment approach in the context of thermal ablation in the liver. At the end of this project, we will have determine d the feasibility of creating local hyperthermia with this device and understand the potential benefits and applications for this approach. PUBLIC HEALTH RELEVANCE: The goal of this Phase I SBIR Grant proposal is to develop a novel catheter technolo gy capable of inducing local hyperthermia and halting blood flow prior to an ablation procedure. The system will be useful for enhancing ablation zone size and may find application with other chemotherapy and radiation based protocols. This proposal is foc used on design, fabrication, and testing of a prototype device in benchtop and pilot animal studies

* information listed above is at the time of submission.

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