CENTRIFUGAL CIRCULATORY ASSIST DEVICE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
3250
Agency Tracking Number:
3250
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2945 Kilgore Rd., Rancho Cordova, CA, 95670
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
R. K. Wampler
Principal Investigator
(916) 638-1451
Business Contact:
() -
Research Institute:
n/a
Abstract
MECHANICAL VENTRICULAR ASSISTANCE HAS PROVEN TO BE AN EFFECTIVE TREATMENT IN THE MANAGEMENT OF CARDIOGENIC SHOCK FOLLOWING OPEN HEART SURGERY AND MYOCARDIAL INFARCTION. PROMISE FOR ITS USE AS A BRIDGE TO CARDIAC TRANSPLANTATION HAS BEEN DEMONSTRATED. INTRA-AORTIC BALLOON COUNTERPULSATION IS THE ACCEPTED TREATMENT FOR CARDIOGENIC SHOCK AND HAS PROVEN EFFECTIVE. HOWEVER, IT HAS LIMITED SUPPORT CAPABILITY AND A LARGE NUMBER OF PATIENTS WITH CARDIOGENIC SHOCK ARE UNRESPONSIVE TO INTRA-AORTIC BALLOON COUNTERPULSATION. PULSATILE VENTRICULAR ASSIST DEVICES CAN PROVIDE MUCH GREATER CIRCULATORY SUPPORT THAN THE INTRA-AORTIC BALLOON PUMP, BUT PRESENT SYSTEMS ARE COSTLY, COMPLEX, BULKY, AND REQUIRE CENTRAL VASCULAR ACCESS VIA MAJOR SURGERY FOR IMPLEMENTATION. SUBSTANTIAL COMMERCIAL OPPORTUNITIES FOR A COST-EFFECTIVE, COMPACT, SIMPLE VENTRICULAR ASSIST SYSTEM EXIST. NIMBUS, INC. HAS COMPLETED INITIAL FEASIBILITY STUDIES OF AN INTEGRATED, COMPACT CENTRIFUGAL PUMP INTENDED FOR USE AS A TEMPORARY VENTRICULAR ASSIST DEVICE. IN VITRO AND IN VIVO STUDIES HAVE DEMONSTRATED ACCEPTABLE HYDRAULIC, HEMOLYSIS, AND HEMODYNAMIC PERFORMANCE. THE PROPOSED EFFORT WILL DEMONSTRATE THE FEASIBILITY OF TECHNOLOGICAL INNOVATION WHICH WOULD PERMIT PRODUCTION OF A COST-EFFECTIVE CENTRIFUGAL VENTRICULAR ASSIST DEVICE. PHASE I VALIDATES INITIAL STUDIES, REFINES THE EXISTING PUMP DESIGN AND COMPLETES THREE 7-DAY IN VIVO EXPERIMENTS IN COLLABORATION

* information listed above is at the time of submission.

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