SBIR Phase I: Vibrational CD Microscopy for Characterizing Supramolecular Bio-Chirality

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0945484
Agency Tracking Number: 0945484
Amount: $125,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: BC
Solicitation Number: NSF 09-541
Small Business Information
BioTools
17546 Bee Line Hwy, JUPITER, FL, 33458
DUNS: 117950563
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Rina Dukor
 PhD
 (561) 625-0133
 rkdukor@aol.com
Business Contact
 Rina Dukor
Title: PhD
Phone: (561) 625-0133
Email: rkdukor@aol.com
Research Institution
N/A
Abstract
This Small Business Innovation Research (SBIR) Phase I project is focused on the creation of a new revolutionary imaging instrumentation that combines vibrational circular dichroism (VCD) spectroscopy with infrared (IR) spectral microscopy. VCD microscopy represents a new class of spectroscopic imaging diagnostic capable of measuring VCD images with millimeter to sub-millimeter spatial resolution. The recent discovery that long-range structural chirality in protein fibrils is characterized by unusually large and distinctive VCD spectra provides the backdrop for this project. None of the currently available techniques can characterize the fibrillation pathway or the final fibril state with the same ease and detail as VCD. VCD microscopy can be thought of as circular polarization contrast microscopy that is sensitive to long-range chiral order in localized regions of biological samples. The broader impacts of this research are studies of the supramolecular chirality of fibrils. This product is not a small improvement of an existing technology but a distinctly new method of studying long-range biochirality that is more sensitive, provides more detail, and is easy and fast to use. A secondary, higher-impact long-term impact will be clinical research laboratories where this innovation can be used for the detection and characterization of amyloids in vivo, i.e. for tissue biopsies, rapid detection of amyloids and drug screening.

* information listed above is at the time of submission.

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