Photochemical Tissue Bonding for Military Medical Applications

Award Information
Agency:
Department of Defense
Branch
Air Force
Amount:
$99,824.00
Award Year:
2007
Program:
STTR
Phase:
Phase I
Contract:
FA9550-07-C-0098
Award Id:
83384
Agency Tracking Number:
F074-033-0346
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
5408 NE 88th Street, Bldg E, Vancouver, WA, 98665
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
799811646
Principal Investigator:
PaulCrump
Principal Scientist
(360) 713-5161
paul.crump@nlight.net
Business Contact:
RossLancaster
Program Manager
(360) 624-6188
ross.lancaster@nlight.net
Research Institute:
OREGON MEDICAL LASER CENTER
Scott A Prahl
9205 SW Barnes Road
Portland, OR, 97225
(503) 216-2197
Domestic nonprofit research organization
Abstract
Joining severed vessels is a recurring problem in trauma and surgery. The basic technology that uses suture has been available for a long time. Many technologies have been introduced to make vessel suturing water-tight. Any solution to this problem must integrate well with standard medical care. This means that the solution must be safe, effective, acceptable to surgeons, and technologically feasible. We propose a novel two-wavelength laser that allows precise and rapid closure of anastomosis of vessels. An exogenous glue, composed of FDA-approved human serum albumin will be used to increase bond strength and burst pressures. A dissolvable stent, also composed of human serum albumin, will be used to facilitate joining larger vessels and aligning the vessel edges. Laser bonding has not gained widespread clinical acceptance because (1) an exogenous chromophore (indocyanine green) was required, (2) no economical laser sources, (3) large laser beam sizes (4) no internal support for the vessel during anastomosis was available. Advances in laser technology at nLight Corp remove issues (2) and (3). The protocol proposed would eliminate issues (1) and (4) - albumin replaces indocyanine green, and internal support is provided by a solid albumin stent, which dissolves once blood is allowed to flow again.

* information listed above is at the time of submission.

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