Photochemical Tissue Bonding for Military Medical Applications

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA9550-07-C-0098
Agency Tracking Number: F074-033-0346
Amount: $99,824.00
Phase: Phase I
Program: STTR
Awards Year: 2007
Solitcitation Year: 2007
Solitcitation Topic Code: AF07-T033
Solitcitation Number: N/A
Small Business Information
NLIGHT PHOTONICS
5408 NE 88th Street, Bldg E, Vancouver, WA, 98665
Duns: 799811646
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Paul Crump
 Principal Scientist
 (360) 713-5161
 paul.crump@nlight.net
Business Contact
 Ross Lancaster
Title: Program Manager
Phone: (360) 624-6188
Email: ross.lancaster@nlight.net
Research Institution
 OREGON MEDICAL LASER CENTER
 Scott A Prahl
 9205 SW Barnes Road
Portland, OR, 97225
 (503) 216-2197
 Domestic nonprofit research organization
Abstract
Joining severed vessels is a recurring problem in trauma and surgery. The basic technology that uses suture has been available for a long time. Many technologies have been introduced to make vessel suturing water-tight. Any solution to this problem must integrate well with standard medical care. This means that the solution must be safe, effective, acceptable to surgeons, and technologically feasible. We propose a novel two-wavelength laser that allows precise and rapid closure of anastomosis of vessels. An exogenous glue, composed of FDA-approved human serum albumin will be used to increase bond strength and burst pressures. A dissolvable stent, also composed of human serum albumin, will be used to facilitate joining larger vessels and aligning the vessel edges. Laser bonding has not gained widespread clinical acceptance because (1) an exogenous chromophore (indocyanine green) was required, (2) no economical laser sources, (3) large laser beam sizes (4) no internal support for the vessel during anastomosis was available. Advances in laser technology at nLight Corp remove issues (2) and (3). The protocol proposed would eliminate issues (1) and (4) - albumin replaces indocyanine green, and internal support is provided by a solid albumin stent, which dissolves once blood is allowed to flow again.

* information listed above is at the time of submission.

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