SBIR Phase II: Fluorescent Polymeric Nanoparticles

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$499,998.00
Award Year:
2003
Program:
SBIR
Phase:
Phase II
Contract:
0239285
Award Id:
62714
Agency Tracking Number:
0239285
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1024 S. Innovation Way, Stillwater, OK, 74074
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Lawrence Hancock
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
This Small Business Innovation Research (SBIR) Phase II project will develop a new generation of fluorescence amplifying reagents based on poly (phenylene ethynylene (PPE)) nanoparticles. Because of the role of the amplifying polymer in the enhanced sensitivity of these compounds, these compounds are called Amplimer reagents. The project will develop and launch two types of Amplimer reagents: microarray and quantitative PCR reagents. The Amplimer reagents will improve the sensitivity and performance of fluorescence-based assays by providing brighter, more stable fluorescence signals and by improving sensitivity through fluorescence amplification effects. The commercial and broader impacts of this technology are consumable fluorescent reagents that improve the sensitivity and reliability of two rapidly growing diagnostic platforms for genetic sequence analysis: microarray-based assays and quantitative PCR assays. Diagnostics based on genetic sequence information currently account for $1 billion of the $24 billion dollar diagnostics market. This figure is expected to grow significantly as the follow-on of the human genome project filters through drug discovery and medical science.

* information listed above is at the time of submission.

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