SuMo SERS: A Novel, High-Reliability CBW Agent Detection System Using Surface-Modified Gold Nanoparticles as a SERS Substrate

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: F49620-03-C-0061
Agency Tracking Number: F033-0304
Amount: $100,000.00
Phase: Phase I
Program: STTR
Awards Year: 2003
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Nomadics, Inc.
1024 S. Innovation Way, Stillwater, OK, 74074
DUNS: 879735579
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Robert Shelton
 Principal Investigator
 (405) 372-9535
 rshelton@nomadics.com
Business Contact
 James Luby
Title: Chief Operating Officer
Phone: (405) 372-9535
Email: jluby@nomadics.com
Research Institution
 MICHIGAN STATE UNIV.
 Gary J Blanchard
 328 Chemistry
East Lansing, MI, 48824
 (517) 355-9715
 Nonprofit college or university
Abstract
Surface Enhanced Raman Spectroscopy (SERS) is a powerful technique for detecting and identifying target analytes, such as CBW agents, even at very small concentrations. However, traditional SERS techniques often suffer from poor reliability andreproducibility. Nanoparticle-based SERS has a tremendous advantage over bulk-surface SERS due to a very high amount of surface area for interaction in a small volume. However, nanoparticles must be carefully stabilized to remain in solution, oftenlimiting their ability to interact with analyte, which is required for SERS.Nomadics proposes to develop an improved SERS technology. Through numerical modeling and optical experimentation, we will determine the optimum shape and size of nanoparticles to maximize the SERS response. We will chemically modify the surface ofnanoparticles to: 1) maintain the nanoparticles suspended in solution, and 2) preferentially bind the target analyte to the nanoparticles, optimizing the SERS response. With this improved SERS platform, we will develop a robust, reliable SERS-based sensortechnology suitable for detecting even trace amounts of CBW agents. Nomadics will develop an improved SERS-based sensor technology suitable for CBW agent detection. This will be useful to both the military and various civilian law enforcement andemergency-response agencies. However, SERS is a very powerful analytical sensing tool, suitable for a broad range of analytes. Trace detection of nearly any chemical or molecular species should be possible with this technology, with a large range ofpotential sensor applications: pesticides, water purity, pharmaceuticals/drug-discovery, etc.

* information listed above is at the time of submission.

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