Nanoparticle Self-Lighting Photodynamic Therapy For Ovarian Cancer Treatment

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-05-C-0101
Agency Tracking Number: A043-187-0258
Amount: $729,992.00
Phase: Phase II
Program: SBIR
Awards Year: 2006
Solicitation Year: 2004
Solicitation Topic Code: A04-187
Solicitation Number: 2004.3
Small Business Information
1024 S. Innovation Way, Stillwater, OK, 74074
DUNS: 879735579
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Wei Chen
 Principal Investigator
 (405) 372-9535
Business Contact
 Jim Luby
Title: Chief Operations Officer
Phone: (405) 372-9535
Research Institution
The goal of the project was to find a more efficient treatment for cancer while reducing the risk of radiation damage. To reach this goal, we propose a novel method for ovarian cancer treatment that combines radiotherapy and photodynamic therapy (PDT). Under this concept, luminescent nanoparticles with attached photosensitizers are used as a new type of agent for photodynamic therapy. In the first year, we will focus on the preparation of highly luminescent nanoparticles by considering size and dielectric confinements and on the conjugation of photosensitizers to nanoparticles. We will characterize the performance of scintillation and long-afterglow nanoparticles in order to ensure the greatest possible chances of success. These nanoparticles will serve as the foundation for a conjugated PDT system. At the end of Year 1, we will use the most promising conjugates to demonstrate PDT against ovarian cancer in vitro. This will constitute a go/no-go point in transitioning to Year 2 and will provide clear demonstration of the feasibility of our PDT nanoparticle system against ovarian cancer. In Year 2, we will enhance the most promising PDT nanoparticle systems toward more efficient PDT and conduct in vivo testing and toxicity evaluation of these systems.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government