Nanoparticle Self-Lighting Photodynamic Therapy For Ovarian Cancer Treatment

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$120,000.00
Award Year:
2005
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-05-C-0101
Award Id:
73711
Agency Tracking Number:
A043-187-0258
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1024 S. Innovation Way, Stillwater, OK, 74074
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
879735579
Principal Investigator:
Wei Chen
Principal Investigator
(405) 372-9535
wchen@nomadics.com
Business Contact:
Jim Luby
Chief Operating Officer
(405) 372-9535
jluby@nomadics.com
Research Institution:
n/a
Abstract
Nomadics is a research and development company that has been quite successful in developing products for the biomedical market. The majority of our research involves the development of advanced materials that are being exploited for commercial applications. In this effort, we propose a novel method for ovarian cancer treatment that combines radiotherapy and photodynamic therapy. Under this concept, luminescent nanoparticles with attached photosensitizers, such as porphyrins, are used as a new type of agent for photodynamic therapy. Upon exposure to ionizing radiation, light will emit from the nanoparticles to activate the photosensitizers; as a consequence, a singlet oxygen is produced to augment the killing of cancer cells by ionizing radiation. With this novel therapeutic approach, no external light is necessary to activate the photosensitizing agent within tumors. Thus, we call this new modality a self-lighting photodynamic therapy (SLPDT). The combination of radiotherapy and photodynamic therapy will provide a less expensive and more efficient treatment for cancer patients. Our photoluminescent nanoparticles have already demonstrated effective biomedical applications, such as in vivo imaging and dosimetry. The proposed work is a natural extension of our current research and commercialization objectives.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government