Multiplexed Immunological Assay on Micro-ring Resonators for Detection of Brain Injury-Specific Biomarkers

Award Information
Agency:
Department of Defense
Amount:
$100,000.00
Program:
STTR
Contract:
W81XWH-05-C-0174
Solitcitation Year:
2005
Solicitation Number:
N/A
Branch:
Army
Award Year:
2005
Phase:
Phase I
Agency Tracking Number:
O054-003-2029
Solicitation Topic Code:
OSD05-T003
Small Business Information
NOMADICS, INC.
1024 S. Innovation Way, Stillwater, OK, 74074
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
879735579
Principal Investigator
 Jean Clarke
 Principal Invest./Microbiologist
 (405) 372-9535
 jclarke@nomadics.com
Business Contact
 Jim Luby
Title: Chief Operations Officer
Phone: (405) 372-9535
Email: jluby@nomadics.com
Research Institution
 MASSACHUSETTS GENERAL HOSPITAL
 Brian J Bacskai
 Alzheimer's Disease Rsrch Unit, 114 16th Street (Rm 2850)
Charlestown, MA, 02129
 (617) 724-5306
 Domestic nonprofit research organization
Abstract
The goal of the proposed research is to develop a highly sensitive, high-throughput, and miniaturized assay system for rapid detection of brain injury-specific biomarkers in serum. The assay will be integrated into a portable detector so results can be immediately communicated to the health-care provider for assessment and appropriate treatment of patient injury. This technology will be particularly important on the battlefield where sophisticated and expensive laboratory analytical equipment and expertise is not readily available. The key technological innovation for this project is called a micro-ring resonator, which undergoes a measurable change in resonant wavelength when light interacts with absorbed mass, such as bio-targets binding to a recognition moiety, on the micro-ring surface. In Phase I, three serum biomarkers for brain injury, S100B, NSE, and GFAP, will be detected using an immunologic assay on the micro-ring surface. To develop this platform, Nomadics proposes to use these high finesse micro-rings that incorporate a novel high index material, HydexT, to develop stable and versatile biophotonic interfaces based on label-free and reagentless immunologic platforms, to provide multiplexing capabilities for high-throughput testing and referencing, and to integrate these into a portable and cost-effective sensor platform.

* information listed above is at the time of submission.

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