3D Scaffold and Stem Cell Based Bioengineered Skin for Treatment of Cutaneous Vesicant Injury

Award Information
Agency:
Department of Defense
Branch
Office for Chemical and Biological Defense
Amount:
$746,164.00
Award Year:
2007
Program:
SBIR
Phase:
Phase II
Contract:
W81XWH-05-C-0128
Agency Tracking Number:
C051-117-0147
Solicitation Year:
2005
Solicitation Topic Code:
CBD05-117
Solicitation Number:
2005.1
Small Business Information
NOMADICS, INC.
1024 S. Innovation Way, Stillwater, OK, 74074
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
879735579
Principal Investigator:
R. Chris Doty
Chemist
(734) 763-8768
kotov@umich.edu
Business Contact:
James Luby
Chief Operations Officer
(405) 372-9535
jluby@nomadics.com
Research Institution:
n/a
Abstract
In this Phase II project Nomadics will novate our research to a spin-out company Nico Technologies. Nomadics will remain a subcontractor during this transition. The team proposes a new treatment for injuries from mustard gas based on biodegradable inverted colloidal crystal scaffolds impregnated with stem cells. Phase I results demonstrated excellent performance of these scaffolds for differentiation of murine embryonic stem cells into skin cell lines. By the end of Phase II, we expect to have enhanced scaffold manufacturing and performed in-vitro optimization of ESC differentiation. We will test cell-free scaffolds for tissue regeneration and develop a preservation protocol. Mice will be tested at the University of Texas Medical Branch for the treatment of mustard gas injuries. The team offers a unique technology proven to be an exceptionally convenient media for stem cell differentiation. A novelty of this approach to vesicant injury treatment is its use of three stem-cell sources: embryonic stem cells, adult stem cells from discarded tissue, and recruitment of the patient’s own stem cells by growth-factor-loaded scaffolds. Our team has a long history of successful collaborative projects. Team member J. Cortiella’s experience with treatment of military burn victims brings knowledge of the real-life problems in combat situations.

* information listed above is at the time of submission.

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