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Multi-modal spatial genomics in the mouse and human brains

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R44MH133530-01A1
Agency Tracking Number: R44MH133530
Amount: $1,337,968.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: 101
Solicitation Number: PA22-176
Timeline
Solicitation Year: 2022
Award Year: 2023
Award Start Date (Proposal Award Date): 2023-06-15
Award End Date (Contract End Date): 2025-05-31
Small Business Information
145 Vista Ave
Pasadena, CA 91107
United States
DUNS: 080426411
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 KIRSTEN FRIEDA
 (626) 314-3460
 kfrieda@spatialgenomics.com
Business Contact
 KIRSTEN FRIEDA
Phone: (631) 889-6186
Email: kfrieda@spatialgenomics.com
Research Institution
N/A
Abstract

SUMMARY
The major goal of this project is to build upon our existing expertise and platform to develop
spatial multi-omics tools in human brains. At Spatial Genomics, we are commercializing the
sequential fluorescence in situ hybridization (seqFISH) technology (Eng et al, 2019) that allows
thousands of genes to be imaged directly in brain samples. We have developed extensive
experience working with mouse and human brains with our seqFISH technology. Spatial
genomics methods have the potential to identify novel cell types, reveal spatial organization of
groups of cells and subcellular patterns, and elucidate signaling interactions between
neighboring cells in the brain. Identifying the spatial organization of the human brain at cellular
resolution from single cell gene expression profiles is essential to understanding neuronal
circuits and interactions between neurons and glia.

* Information listed above is at the time of submission. *

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