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Spatial single cell analysis of the human Alzheimer's Disease brain

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R44AG085832-01
Agency Tracking Number: R44AG085832
Amount: $1,229,313.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: NIA
Solicitation Number: PAS22-196
Solicitation Year: 2022
Award Year: 2023
Award Start Date (Proposal Award Date): 2023-09-21
Award End Date (Contract End Date): 2025-05-31
Small Business Information
145 Vista Ave
Pasadena, CA 91107
United States
DUNS: 080426411
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (626) 314-3460
Business Contact
Phone: (626) 340-0921
Research Institution

The major goal of this project is to study human Alzheimer’s Disease (AD) brains using the
Spatial Genomics GenePS instrument for automated large scale gene expression analysis at
single cell resolution. At Spatial Genomics, we are commercializing the sequential fluorescence
in situ hybridization (seqFISH) technology (Eng et al, 2019) that allows thousands of genes to
be imaged directly in brain samples. We have experience working with human brains with our
seqFISH technology and will hone the technology for use in human brains. Using the seqFISH
method, we will identify changes in cell types, spatial organization of groups of cells, and
signaling interactions between neighboring cells in the human AD brain.

* Information listed above is at the time of submission. *

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