Ambulatory Detection of Asymptomatic Atrial Fibrillation

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$164,882.00
Award Year:
2008
Program:
STTR
Phase:
Phase I
Contract:
1R41HL090106-01A1
Award Id:
89540
Agency Tracking Number:
HL090106
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
NORTHWEST RESEARCH ASSOCIATES, 14508 NE 20TH ST, BELLEVUE, WA, 98007
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
151471349
Principal Investigator:
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): Project Summary/Abstract Atrial fibrillation is the most common disorder of the heart rhythm that requires treatment, with a prevalence estimated at over 5 million in the US alone in the year 2000. If untreated, it is a ssociated with increased risk of death and disability, primarily due to stroke. There is increasing evidence that a significant percentage of atrial fibrillation goes undetected, because it either does not immediately cause symptoms, or is episodic, and no t present in the brief periods that the electrocardiogram is monitored, which are typically for minutes up to two days. Technology developed at the University of Washington allows convenient and accurate monitoring of the electrocardiogram in patie nts outside of the hospital for prolonged periods, up to at least four weeks. The device weighs less than an ounce, and uses built-in intelligence to classify the recorded tracings, looking for atrial fibrillation. This project will have two goals. The first is to directly compare the techniques used in this device to other published techniques, using a previously annotated and classified set of recorded, long-term ECGs. The second is to use the device on subjects with atrial fibrillation undergoing standard 24 or 48 hour monitoring, to compare the yield of atrial fibrillation, and accuracy of determination of duration of atrial fibrillation. PUBLIC HEALTH RELEVANCE Atrial fibrillation is the most common rhythm disorder of the heart which can cause d isability or death, and it affects millions of individuals in the United States. Individuals may have atrial fibrillation without being aware of it. This project will further develop a technology which can inexpensively and comfortably identify subjects wi th intermittent atrial fibrillation but do not experience any symptoms, allowing them to be treated to reduce their risk.

* information listed above is at the time of submission.

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