SBIR Phase I: A New Vaccine Development Method

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0610716
Agency Tracking Number: 0610716
Amount: $99,937.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solicitation Year: 2005
Solicitation Topic Code: CT
Solicitation Number: NSF 05-605
Small Business Information
3109 North Triphammer, Lansing, NY, 14882
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Timothy Christensen
 (607) 330-2772
Business Contact
 Timothy Christensen
Title: Dr
Phone: (607) 330-2772
Research Institution
This Small Business Innovation Research (SBIR) Phase I research project aims to develop a novel method for the production of whole cell vaccines using the supercritical CO2 technology. The majority of current whole cell vaccine preparations are made using formalin inactivation which has numerous drawbacks including residual formaldehyde, denaturation of key antigens, and lack of sterility requiring preservatives. Supercritical CO2 inactivation of leaves no toxic residuals, does not denature proteins, and is inherently sterile. Commercially, the application is a production process for a higher quality vaccine which may require fewer doses as well as open the door to the quick and inexpensive manufacture of vaccines to emerging diseases for which current methodologies do not create useful vaccines, or where these methods are not cost-effective given a small financial return. In addition to the production of new vaccines the sterilization of existing subunit vaccines using this technology will reduce the need for preservatives and increase the safety of vaccine preparations. Both companies and the public health will benefit from safer, higher quality, and less expensive vaccine preparations.

* Information listed above is at the time of submission. *

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