Nanoparticle Based Magnetic Microfluidic concentrator (MMC)

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R41CA130986-01
Agency Tracking Number: CA130986
Amount: $100,000.00
Phase: Phase I
Program: STTR
Awards Year: 2008
Solicitation Year: 2008
Solicitation Topic Code: N/A
Solicitation Number: PHS2007-2
Small Business Information
DUNS: 155516987
HUBZone Owned: Y
Woman Owned: Y
Socially and Economically Disadvantaged: Y
Principal Investigator
 () -
Business Contact
Phone: (479) 236-7147
Research Institution
DESCRIPTION (provided by applicant): Enriched abnormal exfoliated cells and biomolecules will enable genomic, proteomic, and epigenomic analyses to detect cancer-specific alterations in expressed genes, protein/peptide profiles, and epigenetic markers. The ability to carry out such enrichment and analyses in a routine way using body fluids may lead to improvements in cancer detection. This NIH SBIR Phase I proposal is to develop a high throughput and high enrichment factor system for the enrichment o f rare cancer cells and cell fragments. In phase I, the enrichment of cancer cell, cancer protein and all DNAs will be studied through our model system. In phase II, the cancer cells and cell fragment in body fluids will be used to optimize this system. Th e final deliverables will include a MMC, antibody immobilized MNPs and all necessary protocols.

* Information listed above is at the time of submission. *

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