Nanoparticle Based Magnetic Microfluidic concentrator (MMC)
Department of Health and Human Services
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Small Business Information
OCEAN NANOTECH, LLC
OCEAN NANOTECH, LLC, 2143 Worth Lane, SPRINGDALE, AR, 72764
Socially and Economically Disadvantaged:
AbstractDESCRIPTION (provided by applicant): Enriched abnormal exfoliated cells and biomolecules will enable genomic, proteomic, and epigenomic analyses to detect cancer-specific alterations in expressed genes, protein/peptide profiles, and epigenetic markers. The ability to carry out such enrichment and analyses in a routine way using body fluids may lead to improvements in cancer detection. This NIH SBIR Phase I proposal is to develop a high throughput and high enrichment factor system for the enrichment o f rare cancer cells and cell fragments. In phase I, the enrichment of cancer cell, cancer protein and all DNAs will be studied through our model system. In phase II, the cancer cells and cell fragment in body fluids will be used to optimize this system. Th e final deliverables will include a MMC, antibody immobilized MNPs and all necessary protocols.
* information listed above is at the time of submission.