SBIR Phase I: ChromArray, Chrosome Analysis Wafer

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0319105
Agency Tracking Number: 0319105
Amount: $99,920.00
Phase: Phase I
Program: SBIR
Awards Year: 2003
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
1001 Bishop Street, Honolulu, HI, 96813
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Daniel O'Connell
 () -
Business Contact
Phone: () -
Research Institution
This Small Business Innovation Research (SBIR) Phase I project proposes a new technique for rapid Karyotyping based on a "ChromArray" device, which would allow the collection of a large number of chromosome spreads in a precise array. By collecting the inherent spectrum of chromosomes, the addition of dye is not necessary. Each physical coordinate within the karyotype would contain a third axis (spectra), adding further criteria for automated karyotpying of large number of chromosome spreads simultaneously. This project will investigate a technique of karyotyping that permits rapid identification of chromosomal alterations, thereby identifying chromosomal abnormalities of a large array of chromosome samples simultaneously. Therefore a large number of cells from the human body (of which there are 200 cell types) can be studied, to screen for genetic disorders. The commercial application of this project is in the area of human healthcare. The use of chromarray technology and near field optical microscopy would impact a variety of clinical disease assays when completely implemented.

* Information listed above is at the time of submission. *

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