Imaging Device for the Assessment of Airways in Combat Casualties with Inhalation Injury due to Burns, Smoke, or Toxic Gases

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$779,721.00
Award Year:
2009
Program:
SBIR
Phase:
Phase II
Contract:
W81XWH-09-C-0023
Award Id:
87267
Agency Tracking Number:
A2-3836
Solicitation Year:
2008
Solicitation Topic Code:
A08-117
Solicitation Number:
2008.2
Small Business Information
1002 health sciences road, Beckman Laser institute, Irvine, CA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
827567228
Principal Investigator:
Tirunelveli Ramalingam
PI
(310) 254-4962
octmedical@gmail.com
Business Contact:
Tirunelveli Ramalingam
CEO
(310) 254-4962
octmedical@gmail.com
Research Institute:
n/a
Abstract
Inhalation airway injury is a major cause of morbidity and mortality for soldiers in modern combat. In inhalation burn victims, certain pathophysiological changes occur at a very small length scales in airway tissues immediately following exposure. Measuring these changes from within the lumen of airway during bronchoscopy is difficult because these changes occur in sub-mucosa at microscopic level. To solve above problems, OCT Medical Imaging Inc (OCTMI), proposes to develop and test an advanced light-based, fiber-optic imaging system using a platform imaging technology known as Optical Coherence Tomography (OCT). In Phase II, we will extend our successful Phase I results and develop an advanced compact real-time 3D-OCT system incorporating advanced light source. By consulting with clinicians, we pan to develop user-friendly software and test our 3D-OCT probes and OCT systems using an animal smoke inhalation model developed at our collaborators laboratory. Based on above studies, we will refine our 3D-OCT probe, systems and software and evaluate them in bronchoscopic airway detection sensitivity and specificity to gold standard histologic imaging in patients. After successful Phase II, we plan to apply for IDE and seek 510k FDA approval to enter the market.

* information listed above is at the time of submission.

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