A NEW RAPID TEST FOR SALMONELLA DETECTION USING LIPOSOME -ENTRAPPED MOLECULES

Award Information
Agency:
Department of Agriculture
Branch
n/a
Amount:
$200,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
4628
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Ohmicron Corp.
108 West Franklin Ave, Pennington, NJ, 08534
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
DR. MARK MALMROS
() -
Research Institution:
n/a
Abstract
THE TESTING FOR SALMONELLA CURRENTLY INVOLVES METHODOLOGY THAT REQUIRES 3-8 DAYS TO COMPLETE AND A FAIRLY SOPHISTICAT ED SKILL LEVEL TO PERFORM. THIS PROJECT IS DESIGNED TO D DEVELOP BOTH MANUAL AND BIOSENSOR-BASED HOMOGENEOUS ASSAYS THAT WILL REDUCE THE DETECTION TIME OF SALMONELLA TO WITHIN 24 HOURS AND BE TECHNICALLY SIMPLER TO PERFORM. THE NOVEL ASPECT IS THE USE OF A LIMPSOME-ENCAPSULATED ENZYME. THE ENZYME WILL BE RELEASED FROM THE LIPOSOME UPON THE INTER ACTION OF SALMONELLA ORGANISMS WITH A MONOCLONAL ANTIBODY ON THE LIPOSOME SURFACE IN THE PRESENCE OF COMPLEMENT. THE ENZYME WOULD NOW BE FREE TO GENERATE A PRODUCT WHICH WOULD CAUSE A COLOR CHANGE IN THE MANUAL TEST AND A MEASURABLE CONDUCTIVITY CHANGE IN THE BIOSENSOR-BASE TEST.

* information listed above is at the time of submission.

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