DIFFERENTIAL THERMOMETRIC BIOANALYTICAL SENSOR (DTBS)

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$50,000.00
Award Year:
1990
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
11832
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Ohmicron Corp
375 Pheasant Run, Newtown, PA, 18940
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Mark Kent Malmros
Cto
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
BIOSENSORS ARE A RAPIDLY EMERGING BIOTECHNOLOGY ENGINEERING EFFORT THAT IS MULTIDISCIPLINARY, ENCOMPASSING MANY TYPES OFMEASURING TECHNIQUES AND DEVICES. WE PROPOSE TO EXPLORE THEFEASIBILITY OF DEVELOPING A SENSITIVE, MINIATURE DIFFERENTIAL THERMOMETRIC BIOSENSOR DEVICE USING THIN POLYMER FILMS (POLYVINYLIDENE FLUORIDE OR PVDF) DISPLAYING A PYROELECTRIC RESPONSE. BY UTILIZING SUCH TECHNIQUES AS PHOTOLITHOGRAPHIC ETCHING, ELECTROCHEMICAL POLYMERIZATION AND MICROPROCESSOR BASED DATA ACQUISITION AND ANALYSIS, WE ANTICIPATE CONSTRUCTING AND EVALUATING A SIMPLE ENZYME AND IMMUNOCHEMICAL BASED BIOSENSOR DEVICE WHICH IS SENSITIVE, QUANTITATIVE AND INCORPORATING LOW COST FABRICATION TECHNIQUES. A DISTINCT ADVANTAGE OF A THERMOMETRIC BIOSENSOR DEVICE IS THAT A WIDE RANGE OF ANALYSES CAN BE PERFORMED AND THE SPECIFICITY DETERMINED BY THE CHOICE OF BIOLOGICAL PROCESSES WITHOUT THE POTENTIAL OF INTERFERENCES ENCOUNTERED BY METHODS SUCH A SPECTROPHOTOMETRY OR FLUOROMETRY. FURTHER, UNLIKE CALORIMETRIC TECHNIQUES USING THERMISTORS OR THERMOPILES, PYROELECTRIC FILMS CAN BE FABRICATED TO EXTREMELY CLOSE PHYSICAL TOLERANCES BY SIMPLE MEANS AND OPERATED IN A DIFFERENTIAL MODE, IRRESPECTIVE OF THE ABSOLUTE TEMPERATURE. IN EFFECT, WE PROPOSE TO EVALUATETECHNIQUES THAT CAN SIGNIFICANTLY IMPROVE UPON AND SIMPLIFY THE CLASSICAL METHODS OF THERMOMETRY AND MICROCALORIMETRY.

* information listed above is at the time of submission.

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