PROTEIN KINASE C IS ACTIVATED BY TUMOR PROMOTORS AND THERE IS STRONG EVIDENCE THAT IT ACTUALLY MEDIATES TUMOR PROMOTION.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4766
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Oncogene Science Inc
222 Station Plaza North, Suite 330, Mineola, NY, 11501
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 FRED H REYNOLDS JR
 PRINCIPAL INVESTIGATOR
 (516) 877-2882
Business Contact
Phone: () -
Research Institution
N/A
Abstract
PROTEIN KINASE C IS ACTIVATED BY TUMOR PROMOTORS AND THERE IS STRONG EVIDENCE THAT IT ACTUALLY MEDIATES TUMOR PROMOTION. ACTIVATED PROTEIN KINASE C PHOSPHORYLATES THE EPIDERMAL GROWTH FACTOR RECEPTOR GUANYLATE CYCLASE AND SEVERAL OTHER POTENTIALLY REGULATORY PROTEINS; THE PHYSIOLOGICAL SIGNIFICANCE OF THIS PHOSPHORYLATION IS UNDER STUDY IN A NUMBER OF LABORATORIES. IN PHASE I, ONCOGENE SCIENCE WILL (1) DETERMINE THE SUBSTRATE SPECIFICITY OF PROTEIN KINASE C FOR DEFINED SYNTHETIC PEPTIDES; (2) PRODUCEANTIBODIES AGAINST THE OPTIMIZED PEPTIDE SUBSTRATE; (3) SYNTHESIZE INHIBITORS OF PROTEIN KINASE C; (4) DEVELOP SPECIFIC ASSAYS FOR PROTEIN KINASE C-CATALYZED PHOSPHORYLA- TION; AND (5) DEVELOP FLUORESCENT PEPTIDES TO VISUALIZE PROTEIN KINASE C IN CELLS. THE RESULTS OF PHASE I RESEARCH WILL POINT THE WAY TOWARD DESIGN OF A SERUM-BASED DIAGNOSTICASSAY FOR PROTEIN KINASE C AND WILL POTENTIALLY LEAD TO DEVELOPMENT OF POTENT INHIBITORS OF PROTEIN KINASE C. THESEINHIBITORS OF TUMOR PROMOTION COULD BE HIGHLY BENEFICIAL. PROTEIN KINASE C INHIBITORS MIGHT ALSO HAVE APPLICATION IN THE AREAS OF CANCER TREATMENT, IMMUNOMODULATION, AND CANCER RESEARCH.

* information listed above is at the time of submission.

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