MOLECULAR CYTOGENETICS USING ALPHA SATELLITE DNA PROBES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
8029
Agency Tracking Number:
8029
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
209 Perry Pky, Suite 7, Gaithersburg, MD, 20877
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
DIAGNOSIS OF NUMERICAL CHROMOSOME ABNORMALITIES IS ALMOST INVARIABLY BASED ON THE EVALUATION OF MITOTIC CHROMOSOME COMPLIMENTS USING CHROMOSOME BANDING TO FACILITATE INDIVIDUAL CHROMOSOME IDENTIFICATION. CHROMOSOME ANALYSIS HAS BECOME A MAJOR DIAGNOSTIC TOOL IN MANY AREAS OF MEDICINEINCLUDING OBSTETRICS, HEMATOLOGY, ONCOLOGY, AND CLINICAL GENETICS. DESPITE MAJOR ADVANCES IN THE FIELD OF CYTOGENETICS THE DIAGNOSIS OF CHROMOSOME ABNORMALITIES REMAINS A TIME-CONSUMING AND LABOR-INTENSIVE PROCEDURE PERFORMED BY HIGHLY TRAINED AND SKILLED TECHNOLOGISTS. THE OBJECTIVE OF THIS RESEARCH PROPOSAL IS TO TEST THE FEASABILITY OF DEVELOPING A RAPID DNA HYBRIDIZATION-BASED MOLECULAR CYTOGENETIC TEST FOR THE DIAGNOSIS OF CHROMOSOMAL SYNDROMES. THE TEST TO BE DEVELOPED IS BASED UPON HYBRIDIZATION IN SITU OF CHROMOSOME SPECIFIC REPETITIVE DNA PROBES TO DIVIDING OR NON-DIVIDING CELLS AND ON THE RAPID AND SENSITIVE DETECTION OF DIPLOIDY OR ANEUPLOIDY BY IMMUNOFLUORESCENCE OR HISTOCHEMICAL TECHNIQUES.

* information listed above is at the time of submission.

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