SBIR Phase I: A Label-Free SERS-Capture Assay in Microchips for Biological Warfare Agents

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0810335
Agency Tracking Number: 0810335
Amount: $99,998.00
Phase: Phase I
Program: SBIR
Awards Year: 2008
Solicitation Year: N/A
Solicitation Topic Code: EO
Solicitation Number: NSF 07-586
Small Business Information
DUNS: 076890222
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Frank Inscore
 (860) 635-9800
Business Contact
 Frank Inscore
Title: PhD
Phone: (860) 635-9800
Research Institution
This Small Business Innovation Research Phase I project develops assay chips that can detect, identify, and quantify the presence of Category A or B bioagents at the required sensitivity within 10 minutes. The assay chips will employ silver particles in a porous sol-gel to selectively extract and bind a specific bioagent with detection using surface-enhanced Raman spectroscopy (SERS). The chips will be part of an analyzer that also includes an aerosol collector and a field usable Raman spectrometer. Feasibility of the approach will be demonstrated during Phase I by developing the silver functionalization method to bind Bacillus cereus and Bacillus subtilis spores, and to detect the capture event by SERS. During the Phase II project, assay chips will be developed and field-tested for several Category A or B bioagents. The broader impacts of this research an enchancement of our ability to monitor public places targeted by terrorists, and to implement rapid response and countermeasures. This information will save lives and substantially reduce the terror associated with such attacks. The device can also be adapted to detect more common Category B pathogens regarding food and water safety (e.g. E. coli 0157:H7).

* Information listed above is at the time of submission. *

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