CW Agent FRET-Aptamer Spray & Compact Scanner

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$98,994.00
Award Year:
2005
Program:
SBIR
Phase:
Phase I
Contract:
W31P4Q-06-C-0047
Award Id:
74338
Agency Tracking Number:
05SB2-0416
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4100 N. W. Loop 410, Suite 230, San Antonio, TX, 78229
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
154088710
Principal Investigator:
John Bruno
Senior Scientist
(210) 731-0015
john.bruno@otcorp.com
Business Contact:
William Henderson
Corporate Financial Officer
(210) 731-0000
bhenders@otcorp.com
Research Institution:
n/a
Abstract
Operational Technologies Corporation (OpTech) will develop and demonstrate a cocktail of several Fluorescence Resonance Energy Transfer (FRET)-DNA aptamer sequences of different analyte specificity in a single spray during Phase I for low-level detection of low-volatility chemical warfare (CW) agent simulants on surfaces and equipment. The fluorophore and quencher will be incorporated into a single DNA chain aptamer structure so that fluorescent light will be emitted ("lights on") or quenched ("lights off") only if the specific CW simulant binds to the FRET-aptamer. In Phase II, OpTech will clone and sequence the CW agent aptamers, and develop a compact surface scanner in conjunction with its subcontractor (Taboada Research Instruments). Upon completion of Phase II, OpTech will deliver the integrated fluorometric scanner and FRET-aptamer spray system to DARPA for further testing and validation.

* information listed above is at the time of submission.

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