Basic Information

SAN DIEGO, CA, 92121-1312


Company Profile


Additional Details

Field Value
DUNS: 103462128
Hubzone Owned: N
Socially and Economically Disadvantaged: N
Woman Owned: N
Number of Employees: 7

  1. Small Molecule Target for Inhibition of Cortisol in Cushing's Syndrome

    Amount: $223,229.00

    ? DESCRIPTION (provided by applicant): Endogenous Cushing's syndrome is a classic dysfunction of the endocrine system caused by prolonged exposure to inappropriately high levels of cortisol. ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Selectin targeted ultrasound contrast agents for detection of acute coronary synd

    Amount: $446,635.00

    DESCRIPTION (provided by applicant): Retinitis pigmentosa (RP), a hereditary disease of the retina affecting 100,000 Americans, is the major cause of blindness in adults aged 25-60. There is no approv ...

    SBIR Phase I 2013 Department of Health and Human Services
  3. Neural Stem Cell-Selective Drug Target for Small Molecule Therapy of Brain Tumors

    Amount: $250,507.00

    DESCRIPTION (provided by applicant) Median survival from time of diagnosis of glioblastoma multiforme (GBM) or stage IV glioma, the most malignant form of brain cancer, is about one year, despite the ...

    SBIR Phase I 2012 Department of Health and Human Services
  4. A Novel Target for the Treatment of Endometriosis

    Amount: $220,839.00

    DESCRIPTION (provided by applicant): Endometriosis is a major cause of severe pelvic pain, pain during menstruation, dyspareunia and infertility in women of child-bearing age with an estimated 22 bil ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Inhibitor of Adrenal Steroid Synthesis for Cancer Treatment

    Amount: $520,358.00

    DESCRIPTION (provided by applicant): Orphagen has identified antagonists to an orphan receptor that regulates the major biosynthetic steps of steroid hormone synthesis in the adrenal cortex and gona ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Novel CNS Target for Sleep-Wake and Psychiatric Disorders

    Amount: $961,179.00

    DESCRIPTION (provided by applicant): Circadian regulation of behavioral, metabolic, and endocrine function is a fundamental homeostatic process. Disruption of the circadian clock has been linked to sl ...

    SBIR Phase II 2009 Department of Health and Human Services
  7. Small Molecule Inhibitors of Effector Th-17 Cells in Inflammatory Bowel Disease

    Amount: $266,559.00

    DESCRIPTION (provided by applicant): Inflammatory bowel disease (IBD), including Crohn's Disease and ulcerative colitis (UC), is a lifelong T cell- mediated inflammatory condition of the small intesti ...

    SBIR Phase I 2008 Department of Health and Human Services
  8. Feasibility Study of Novel Drug Target for Multiple Sclerosis

    Amount: $513,786.00

    DESCRIPTION (provided by applicant): A novel class of T helper cell, distinct from TH1 and TH2 cells, has been implicated in the development of murine experimentally-acquired encephalomyelitis (EAE), ...

    SBIR Phase I 2007 Department of Health and Human Services
  9. Small molecule target for suppression of autoimmunity in rheumatoid arthritis

    Amount: $258,166.00

    DESCRIPTION (provided by applicant): The pro-inflammatory cytokine IL-17 has been implicated in joint destruction and in the inflammatory pathogenesis of rheumatoid arthritis (RA) in human studies. Ta ...

    SBIR Phase I 2007 Department of Health and Human Services
  10. Therapeutic Target for Atherogenic & Metabolic Syndromes

    Amount: $218,858.00

    DESCRIPTION (provided by applicant): The central goal of this project is to identify potent and specific small molecule ligands to the orphan nuclear receptor RORalpha (NR1F1). As a drug target, RORal ...

    SBIR Phase I 2005 Department of Health and Human Services

Agency Micro-sites

US Flag An Official Website of the United States Government