ORPHAGEN PHARMACEUTICALS

Company Information

Company Name
ORPHAGEN PHARMACEUTICALS
Address
11558 SORRENTO VALLEY RD STE 4
SAN DIEGO, CA, 92121-1312
Phone
n/a
URL
http://www.orphagen.com
DUNS
103462128
Number of Employees
8
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N

Award Totals

PROGRAM/PHASE
AWARD AMOUNT ($)
NUMBER OF AWARDS
SBIR Phase I
$4,293,361.00
13
SBIR Phase II
$961,179.00
1

Award List

  1. Inhibitor of Adrenal Steroid Synthesis for Cancer Treatment

    Amount: $520,358.00

    DESCRIPTION (provided by applicant): Orphagen has identified antagonists to an orphan receptor that regulates the major biosynthetic steps of steroid hormone synthesis in the adrenal cortex and gona ...

    SBIR Phase I 2010 Department of Health and Human Services
  2. Adrenal Androgen Blockade for Metastic Prostate Cancer

    Amount: $499,746.00

    DESCRIPTION (provided by applicant): Prostate cancer is the second most common cause of cancer death among men in the United States. The first-line therapy for metastatic prostate cancer is suppress ...

    SBIR Phase I 2003 Department of Health and Human Services
  3. Novel Drug Target for Bile and Cholesterol Metabolism

    Amount: $144,158.00

    DESCRIPTION (provided by applicant): Regulation of bile acid metabolism is a therapeutic target for treatment of hypercholesterolemia as well as for cholestasis, the pathological buildup of bile in li ...

    SBIR Phase I 2003 Department of Health and Human Services
  4. Thymocyte Drug Target of Immune Reconstitution

    Amount: $270,181.00

    DESCRIPTION (provided by applicant): The long-term objective of this proposal is to develop the first class of small molecule, orally-bioavailable drugs that increases T cell production from the thymu ...

    SBIR Phase I 2004 Department of Health and Human Services
  5. Therapeutic Target for Atherogenic & Metabolic Syndromes

    Amount: $218,858.00

    DESCRIPTION (provided by applicant): The central goal of this project is to identify potent and specific small molecule ligands to the orphan nuclear receptor RORalpha (NR1F1). As a drug target, RORal ...

    SBIR Phase I 2005 Department of Health and Human Services
  6. Small Molecule Ligand Discovery for Sleep Cycle Disorders

    Amount: $460,339.00

    DESCRIPTION (provided by applicant): The central circadian regulator of the brain, the suprachiasmatic nucleus (SCN), has been implicated in the pathology of sleep disorders. Deterioration of sleep co ...

    SBIR Phase I 2005 Department of Health and Human Services
  7. Feasibility Study of Novel Drug Target for Multiple Sclerosis

    Amount: $513,786.00

    DESCRIPTION (provided by applicant): A novel class of T helper cell, distinct from TH1 and TH2 cells, has been implicated in the development of murine experimentally-acquired encephalomyelitis (EAE), ...

    SBIR Phase I 2007 Department of Health and Human Services
  8. Small molecule target for suppression of autoimmunity in rheumatoid arthritis

    Amount: $258,166.00

    DESCRIPTION (provided by applicant): The pro-inflammatory cytokine IL-17 has been implicated in joint destruction and in the inflammatory pathogenesis of rheumatoid arthritis (RA) in human studies. Ta ...

    SBIR Phase I 2007 Department of Health and Human Services
  9. Small Molecule Inhibitors of Effector Th-17 Cells in Inflammatory Bowel Disease

    Amount: $266,559.00

    DESCRIPTION (provided by applicant): Inflammatory bowel disease (IBD), including Crohn's Disease and ulcerative colitis (UC), is a lifelong T cell- mediated inflammatory condition of the small intesti ...

    SBIR Phase I 2008 Department of Health and Human Services
  10. Novel CNS Target for Sleep-Wake and Psychiatric Disorders

    Amount: $961,179.00

    DESCRIPTION (provided by applicant): Circadian regulation of behavioral, metabolic, and endocrine function is a fundamental homeostatic process. Disruption of the circadian clock has been linked to sl ...

    SBIR Phase II 2009 Department of Health and Human Services

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