ELECTROMAGNETIC STIMULATION OF CARTILAGE TISSUE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
16344
Agency Tracking Number:
16344
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2850 S 36th Street, Phoenix, AZ, 85040
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Magee, Frank P
Principal Investigator
(602) 437-5520
Business Contact:
1 R43 AR40673-01A1
() -
Research Institution:
n/a
Abstract
DYSFUNCTION OF HUMAN ARTICULAR CARTILAGE DUE TO WEAR, TRAUMA, OR DISEASE, IS BECOMING AN INCREASING SOURCE OF PAIN, DISABILITY, AND HEALTH CARE EXPENDITURES. NONE OF THE PRESENTLY AVAILABLE TREATMENTS OFFERS AN ADEQUATE LONG TERM SOLUTION TO THIS PROBLEM. ELECTROMAGNETIC (EM) FIELDS HAVE BEEN SUCCESSFULLY USED TO STIMULATE HEALING OF RECALCITRANT BONE FRACTURES AND TO PROMOTE HEALING OF SPINAL FUSIONS. CARTILAGE HAS AN ELECTROGENERATIVE PROPERTY SIMILAR TO BONE'S AND THUS THE EXTERNAL APPLICATION OF ELECTROMAGNETIC FIELDS TO STUDY STIMULATED CARTILAGE TISSUE REPAIR IS JUSTIFIED. THE OBJECTIVE OF THIS STUDY IS TO ESTABLISH A FREQUENCY DOSE-BIOLOGICAL RESPONSE DATABASE FOR AN ESTABLISHED EX VIVO CARTILAGE TISSUE MODEL. SINUSOIDAL WAVEFORMS HAVING FREQUENCIES OF 15.3, 25.5 AND 76.5 HERTZ WILL BE APPLIED IN TWO GROUPS; GROUP ONE USES AMBIENT STATIC MAGNETIC FIELDS WHILE GROUP TWO USES A CONTROLLED STATIC MAGNETIC FIELD (0.200 GAUSS) WHICH SATISFIES THE RESONANCE CONDITIONS FOR CA+2 (15.3HZ), MG+2 (25.5 HZ) AND COMBINED CA+2 AND MG+2 (76.6 HZ). THE RESPONSE WILL BE QUANTIFIED BY LIQUID SCINTILLATION COUNTING OF INCORPORATED RADIOLABELLED THYMIDINE, SULPHUR, AND HYDROXYPROLINE TO MEASURE SYNTHESIS OF DNA, PROTEOGLYCANS, AND COLLAGEN. THIS STUDY WILL CONTRIBUTE TO THE DATA BASE OF LOW FREQUENCY EM STIMULATION, TEST THE CYCLOTRON RESONANCE THEORY IN THIS MODEL, AND MAY PROVIDE THE BASIS FOR A HUMAN CLINICAL STUDY.

* information listed above is at the time of submission.

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