Microarray chips for rapid detection of high affinity nucleic acid sequences

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43GM076811-01A1
Agency Tracking Number: GM076811
Amount: $112,494.00
Phase: Phase I
Program: SBIR
Awards Year: 2006
Solicitation Year: 2006
Solicitation Topic Code: N/A
Solicitation Number: PHS2006-2
Small Business Information
ORTHOSYSTEMS, INC.
2-212 CTR FOR SCI & TECH, 111 COLLEGE PL, SYRACUSE, NY, 13244
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MARK MCPIKE
 (315) 443-5356
 MPMCPIKE@ORTHOBIOSYSTEMS.COM
Business Contact
 MARK MCPIKE
Phone: (315) 633-2423
Email: mpmcpike@orthobiosystems.com
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): This phase I project aims at demonstrating a method to rapidly discover short sequences that bind tightly to protein targets. Our plan in phase I is limited to proof of principle by screening against fluorescently tagged proteins, which will facilitate analysis. In phase II label-free detection methods of analysis will be pursued in an effort to generalizes the screening method. Oligonucleotides discovered in these screens can be engineered into sensors having exquisite sensitivity and selectivity for diagnostics and drug discovery applications.

* information listed above is at the time of submission.

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