CONTROLLED ANTIGEN RELEASE OF SWINE VACCINES USING BIOABSOR-ABLE POLYMERS

Award Information
Agency: Department of Agriculture
Branch: N/A
Contract: N/A
Agency Tracking Number: 9313
Amount: $48,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Oxford Veterinary Laboratories
Number One Bio Drive, Worthington, MN, 56187
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DR JACK H CARLSON
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
CURRENT SWINE VACCINATION PROGRAMS REQUIRE SPECIFIC PERIODS WHEN THE PRODUCTS ARE ADMINISTERED AS WELL AS MULTIPLE DOSES TO BE EFFECTIVE. THE ABILITY TO OFFER MORE FLEXIBLE SCHEDULES WITH CONTROLLED ANTIGEN RELEASE AND FEWER INJEC- STRESS ON THE ANIMALS LOWER COSTS TO THE PRODUCER, IMPROVED EFFICACY AND LONGER IMMUNITY. THIS PROPOSAL DESCRIBES A FEASIBILITY STUDY FOR USING BIOAB-SORBABLE POLYMERS AS ADJUVANTS TO DEVELOP NOVEL AND SUPERIORSWINE BIOLOGICALS. USING PSEUDORABIES VIRUS (PRV) AS A MOD-EL, THE PROPOSED RESEARCH IN PHASE I IS DESIGNED TO ACCESS THE KINETICS OF ANTIGEN RELEASE AND THE LEVEL AND DURATION OF ANY ACCOMPANYING IMMUNE RESPONSE. TISSUE COMPATIBILITY OF THE POLYMER VACCINE IN SWINE WILL ALSO BE DETERMINED. TWO CONCENTRATIONS[10(7.3),OR 10(7.8) TDID50] OF INACTIVATEDPRV WILL BE ENCAPSULATED INTO A POLY-(ESTERAMIDE) MATERIAL. THE VIRUS-FILLED CAPSULE WILL BE INJETED INTO PRV NEGATIVE PIGS AND THE ANIMALS WILL BE SEROLOGICALLY MONITORED OVER A FIVE-MONTH PERIOD FOR RELEASE OF THE VIRUS. ANIMALS WILL BE SACRIFICED MONTHLY AND TISSUE FROM THE INJECTION SITE WILL BE EXCISED AND ANALYZED FOR HISTOPATHOLOGY.

* information listed above is at the time of submission.

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