SSRI for Treating Depressed HIV Patients

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$107,366.00
Award Year:
2001
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
1R43MH065712-01
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
PHASE-TWO DISCOVERY, INC.
3130 HIGHLAND AVE, 3RD FL, CINCINNATI, OH, 45219
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
JAMES MULCHAHEY
() -
Business Contact:
(513) 558-4274
Research Institution:
n/a
Abstract
DESCRIPTION: (Verbatim from the Applicant's Abstract) The goal of this Phase I SBIR application is to develop a long acting injectable antidepressant for use in depressed, non-compliant HIV-seropositive individuals. HIV-seropositive individuals have increased rates of depression and medication non-compliance. We have developed a synthetic approach for substituting a decanoate moiety on the free amine of antidepressants resulting in a long acting compound. Sertraline has certain pharmacokinetic advantages over other antidepressants. The proposed studies will develop sertraline decanamide as a long acting antidepressant for parenteral administration. Our Specific Aims are: Specific Aim 1: Manufacture sufficient sertraline decanamide for proposed studies. Specific Aim 2: Determine the dose-response curves of sertraline decanamide (i.m. in oil) and sertraline HCI for inhibiting serotonin uptake by rat brain synaptosomes after in vivo administration. Specific Aim 3: Determine the selectivity of sertraline decanamide and sertraline HCI for inhibiting serotonin uptake in vitro. Concentration-response curves for the in vitro inhibition of synaptosomal norepinephrine, dopamine and serotonin uptake will be generated for the two compounds and compared. Specific Aim 4: Determine the long-term time course (0 to 28 days) for inhibition of synaptosomal serotonin uptake by sertraline decanamide (i.m. in oil) and sertraline HCI after a single dose. PROPOSED COMMERCIAL APPLICATION: Not Available

* information listed above is at the time of submission.

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