BIOMARKER FOR SUBARACHNOID HEMORRHAGE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43NS040175-01A2
Agency Tracking Number: NS040175
Amount: $128,125.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
PHASE 2 DISCOVERY, INC., 3130 HIGHLAND AVE, 3RD FL, CINCINNATI, OH, 45219
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 FRANK ZEMLAN
 (513) 475-6618
 FZEMLAN@PHASE2D.COM
Business Contact
 JAMES HILLARD
Phone: (513) 558-4274
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): The objective of this Phase I application is to develop a new quantitative clinical biomarker for subarachnoid hemorrhage (SAH). Acute headache is initially screened for SAH by computed tomography (CT). CT-negative patients suspected of SAH are then screened for cerebrspinal fluid (CSF) xanthochromia, which has documented limitations and is not FDA-approved. The present application proposes to develop a new biomarker, cleaved MAP-tau (C-tau). The proposed biomarker should demonstrate increased sensitivity and specificity, as well as, improving point of care treatment by using immunocard technology. We have developed a sandwich ELISA that specifically quantifies this neuronally localized protein, C-tau, that is released from damaged neurons. Employing our C-tau ELISA, we demonstrate in preliminary studies that CSF C-tau levels are elevated 1 ,000 fold in SAH patients compared to neurologic controls. Our Specific Aims are: Specific Aim 1: Determine if CSF C-tau levels are significantly elevated in CT-negative acute headache patients with SAH compared patients without SAH determined at three month follow up (N=150). Specific Aim 2: Determine if differences in CSF C-tau level between SAH(+) and SAH(-) patients are time dependent (Specific Aim 1).

* Information listed above is at the time of submission. *

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