THE OBJECTIVE OF THIS PROJECT IS TO SYNTHESIZE NEW GOSSYPOL DERIVATIVES FOR USE AS MALE CONTRACEPTIVES.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4846
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Pacific Rim Bioscience Ent
182 South Nardo Ave, Solana Beach, CA, 92075
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MICHAEL E BAKER
 PRINCIPAL INVESTIGATOR
 (619) 755-7405
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE OBJECTIVE OF THIS PROJECT IS TO SYNTHESIZE NEW GOSSYPOL DERIVATIVES FOR USE AS MALE CONTRACEPTIVES. THE FACT THAT GOSSYPOL ITSELF IS ALREADY BEING USED AS A MALE CONTRA- CEPTIVE AGENT IN CHINA, AND THE NEED FOR AN INEXPENSIVE, REVERSIBLE, NONTOXIC MALE CONTRACEPTIVE IN DEVELOPING COUNTRIES INDICATES THAT NEW, MORE POTENT GOSSYPOL DERIVATIVES WILL BE COMMERCIALLY SUCCESSFUL. THE GOSSYPOL DERIVATIVES WILL BE TESTED FOR ABILITY TO INHIBIT ANDROGEN AND ESTROGEN BINDING TO PROTEINS, SPERM MOBILITY, AND SPERM METABOLISM. SUFFICIENT QUANTITIES OF THESE ANALOGUES FOR LATER IN VIVO STUDIES (PHASE II) WITH RATS AND HAMSTERS WILLPREPARED. LATER STUDIES (PHASE II) MAY ALSO INCLUDE TESTINGTHESE GOSSYPOL DERIVATIVES FOR ABILITY TO INHIBIT THE GROWTHOF TRYPANOSOMA CRUZI AND KILLING HERPES VIRUS.

* information listed above is at the time of submission.

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