Three-Dimensional Matrices for Cellular and Multicellular Biointerfaces

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$98,981.00
Award Year:
1998
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
40425
Agency Tracking Number:
40425
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1400 Key Boulevard, Suite 700, Arlington, VA, 22209
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Charles Daitch
(804) 923-3673
Business Contact:
() -
Research Institute:
n/a
Abstract
Biological macromolecules are highly efficient at recognizing specific analytes or catalyzing reactions in aqueous biological media; however, their natural liquid environment limits military practicality. Any delineation from the preferred buffered aqueous environment results in partial or total loss of reactivity. It would be advantageous to immobilize biological macromolecules in alternative environments that stabilize them and preserve their reactivities. The proposed effort introduces a revolutionary matrix called aerogel to immobilize cells resulting in a biologically active solid matrix. Sof-gel chemistry will be utilized to immobilize the cells in the silica matrix. The silica matrix has an extremely large internal surface area, low density, high porosity, and adjustable pore size, which together render a highly efficient, lightweight matrix for cell immobilization. Also, the silica matrix provides a protective environment for cells, thus increasing shelf life and reactivity.

* information listed above is at the time of submission.

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