COMPUTER SOFTWARE FOR HYPERTHERMIA TREATMENTS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$488,000.00
Award Year:
1989
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
7125
Agency Tracking Number:
7125
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Po Box 71 Etna Road, Hanover, NH, 03755
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Arkady S Dvinsky Phd
(603) 643-3800
Business Contact:
() -
Research Institute:
n/a
Abstract
STRONG EVIDENCE EXISTS THAT ELEVATED TEMPERATURES, IN THE RANGE OF 42 TO 45 DEGREES(C) (HYPERTHERMIA), ARE AN IMPORTANT FACTOR IN THE DESTRUCTION OF CANCER CELLS, ESPECIALLY WHEN COMBINED WITH RADIATION THERAPY AND CHEMOTHERAPY. PRODUCING A CONTROLLED-TEMPERATURE DISTRIBUTION OF A GIVEN MAGNITUDE IS CRITICAL TO THE SUCCESS OF HYPERTHERMIA TREATMENT. RECENT ADVANCES IN COMPUTER TECHNOLOGY HAVE MADE NUMERICAL MODELING OF HYPERTHERMIA TREATMENT A VIABLE ALTERNATIVE FOR PREDICTING THE TEMPERATURE DISTRIBUTION IN TISSUE. CREARE, INC. PROPOSES TO DEVELOP AND TEST A THREE-DIMENSIONAL COMPUTER MODEL FOR QUANTITATIVE THERMAL DOSIMETRY TO BE USED IN HYPERTHERMIA TREATMENTS. BASED ON THE SPECIFIED ANATOMY OF THE PATIENT AND THE CHARACTERISTICSOF THE HEATING DEVICE, A COMPUTER PROGRAM WILL PREDICT POWERDEPOSITION AND TEMPERATURE FIELDS IN THE TISSUE. THE CALCULATED RESULTS WILL BE DISPLAYED INTERACTIVELY IN GRAPHIC AND ALPHANUMERIC FORM. THE DEVELOPED SOFTWARE WILL BE A POWERFUL TOOL FOR PATIENT TREATMENT PLANNING, DESIGN & TESTING OF EQUIPMENT, POSTTREATMENT EVALUATION, AND SCIENTIFIC RESEARCH. IN PHASE I, SPECIFICATIONS FOR THE COMPUTER MODEL OF HYPERTHERMIA TREATMENT WILL BE DEVELOPED. IN ADDITION, A COMPUTER PROGRAM FOR CALCULATING POWER DEPOSITION IN REALISTIC TWO-DIMENSIONAL GEOMETRIES WILL BE IMPLEMENTED.

* information listed above is at the time of submission.

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