ANTITUMOR AND ANTI-HIV ACTIVITY OF A NOVEL INTERFERON

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
19076
Agency Tracking Number:
19076
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1 Progress Boulevard Box 26, Alachua, FL, 32615
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Carol H Pontzer
(904) 392-6885
Business Contact:
() -
Research Institute:
n/a
Abstract
THE PHASE I OBJECTIVE IS TO ASSESS THE POTENTIAL FOR ANTITUMOR EFFECTS OF A NOVEL ALPHA INTERFERON (IFNALPHA), OVINE TROPHOBLAST PROTEIN-1 (OTP-1), AS WELL AS ITS ACTIVITY AGAINST HUMAN AND FELINE IMMUNODEFICIENCY VIRUS (HIV, FIV) INFECTIONS. SEVERAL CHARACTERISTICS OF OTP-1 MERIT ITS INVESTIGATION AS AN ANTITUMOR AGENT AND POTENTIALLY THERAPEUTIC FOR HUMAN AND FELINE AIDS. OTP-1 IS AS POTENT AN ANTIVIRAL AGENT AS ANY KNOW IFN, AND IMPORTANTLY, DISPLAYS ANTICELLULAR ACTIVITY IN THE ABSENCE OF TOXICITY. IT ACTS ON HUMAN CELLS BOTH IN ANTIVIRAL ASSAYS AND IN INHIBITION OF HIV REVERSE TRANSCRIPTASE ACTIVITY. OTP-1 IS AVAILABLE IN BOTH "NATURAL" AND RECOMBINANT FORMS IN LARGE QUANTITIES, AND THE FUNCTIONALLY IMPORTANT PORTIONS OF THE MOLECULE HAVE BEEN LOCALIZED ALLOWING FOR THE DEVELOPMENT OF AGONISTS AND ANTAGONISTS. WE WILL EMPLOY THE FOLLOWING SPECIFIC AIMS: (1) DETERMINE THE ANTINEOPLASTIC ACTIVITY OF OTP-1 IN VITRO AGAINST A PANEL OF TUMOR CELL LINES, (2) EXAMINE THE ANTIVIRAL ACTIVITY OF OTP-1 AND OTP-1 PEPTIDES RELATIVE TO OTHER IFNS IN HIV AND FIV INFECTION, (3) INCREASE THE THERAPEUTIC POTENTIAL OF OTP-1 BY EXAMINING RECOMBINANT OTP-1 AND HUMAN IFNALPHA CHIMERAS AND CONSTRUCTION OF OTP-1 MUTANTS WITH ENHANCED ACTIVITY AGAINST TUMOR CELLS AND HIV AND FIV INFECTIONS. SINCE IFN ALPHAS HAVE BEEN SHOWN TO BE EFFECTIVE ANTITUMOR AGENTS IN CLINICAL TRIALS AND OTP-1 HAS DEMONSTRATED POTENT ANTICELLULAR ACTIVITY WITHOUT TOXICITY, WE ANTICIPATE THAT OTP-1 WILL PROVE TO BE AN INVALUABLE TOOL IN ANTITUMOR THERAPY.

* information listed above is at the time of submission.

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