THE SYNTHESES OF 23 CHOLECYSTOKININ-OCTAPEPTIDE ANALOGUES AND PEPTIDE ANTAGONISTS ARE PROPOSED.

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$35,000.00
Award Year:
1984
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
1798
Agency Tracking Number:
1798
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4970 Battery Lane, #508, Bethesda, MD, 20814
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
MARTHA KNIGHT
DIRECTOR
() -
Business Contact:
Martha Knight
Director Of Research
() -
Research Institution:
n/a
Abstract
THE SYNTHESES OF 23 CHOLECYSTOKININ-OCTAPEPTIDE ANALOGUES AND PEPTIDE ANTAGONISTS ARE PROPOSED. THE PREPARATION OF THESE PEPTIDES WILL INVOLVE SOLID-PHASE TECHNIQUES AND PURIFICATION ON A NEW INSTRUMENT FOR COUNTERCURRENT CHROMATOGRAPHY, THE HORIZONTAL FLOW-THROUGH COIL PLANET CENTRIGUGE. THE BINDING OF THESE PEPTIDES TO CHOLECYSTOKININCENTRAL NERVOUS SYSTEM AND PANCREATIC RECEPTORS WILL BE DETERMINED. ADDITIONALLY, THE PEPTIDES WILL BE SCREENED FOR EITHER AGONIST ACTIVITY OR ANTAGONISM IN ANIMAL BEHAVIOR PARADIGMS AND IN GUINEA PIG PANCREATIC ACINAR CELL SECRETION. THUS POTENTIAL CENTRALLY, BEHAVIORALLY AND PHYSIOLOGICALLY ACTIVE PEPTIDES, SUITABLE FOR THE STUDY OF CHOLECYSTOKININ FUNCTION WILL BE IDENTIFIED. THE PEPTIDES ARE TO BE MADE AVAILABLE FOR RESEARCH IN FOOD-RELATED BEHAVIORS AND PRE-CLINICAL RESEARCH IN AREAS RELATING TO NEUROLOGICAL AND GASTROINTESTINAL DISEASES. METHODS TO PREPARE LARGE AMOUNTS OF THE MOST ACTIVE PEPTIDESARE PROPOSED TO BE DEVELOPED. THESE INCLUDE MODIFICATION OF THE CHEMICAL SYNTHETIC PROCEDURE AND USE OF A PREPARATIVE- SCALE COIL PLANET CENTRIFUGE TO BE CUSTOM BUILT FOR THIS PURPOSE.

* information listed above is at the time of submission.

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