SYNTHESIS OF VISCOSIN, A POTENTIAL THERAPEUTIC FOR CHAGAS' DISEASE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4700
Amount: $204,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Peptide Technologies Corp.
4970 Battery Lane, Suite 508, Bethesda, MD, 20814
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Terrence R Burke Jr
 Principal Investigator
 (202) 234-3384
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE ANTIBIOTIC VISCOSIN, A CYCLIC DEPSIPEPTIDE ISOLATED FROMPSEUDOMONAS VISCOSA, SHOWS PROMISING IN VITRO AND IN VIVO (MICE) CYTOTOXICITY AGAINST TRYPANOSOMA CRUZI, THE CAUSATIVEAGENT IN CHAGAS" DISEASE. THE TOTAL SYNTHESIS OF VISCOSIN IS PROPOSED IN ORDER TO CONFIRM ITS CHEMICAL STRUCTURE AND AND TO PROVIDE MATERIAL FOR RESEARCH. METHODS DEVELOPED DURING SYNTHESIS WILL BE USEFUL FOR FUTURE SYNTHESIS OF FRAGMENTS AND ANALOGS NECESSARY TO DETERMINE THE STRUCTURE- ACTIVITY RELATIONSHIPS OF THE COMPOUND. VISCOSIN AND RELATED COMPOUNDS REPRESENT A POTENTIAL CLASS OF CHEMOTHERAPEUTIC AGENTS FOR CHAGAS' DISEASE WHICH AT PRESENTIS AN INCURABLE AND POTENTIALLY FATAL DISEASE AFFECTING MILLIONS OF PEOPLE.

* information listed above is at the time of submission.

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