CHOLECYSTOKININ ANTAGONISTS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1990
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
13848
Agency Tracking Number:
13848
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
125 Michigan Ave Ne #368 Main, Washington, DC, 20017
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Martha Knight
(202) 234-3384
Business Contact:
() -
Research Institution:
n/a
Abstract
POSSIBLE THERAPEUTICS FOR NEUROENDOCRINE AND GASTROINTESTINAL TUMORS AND NEUROPSYCHIATRIC DISEASES MAY BE DEVELOPED FROM PEPTIDE ANTAGONISTS OF THE CENTRAL NERVOUSSYSTEM CHOLECYSTOKININ RECEPTOR. STRUCTURALLY MODIFIED CHOLECYSTOKININ OCTAPEPTIDE FRAGMENTS WILL BE TESTED FOR INTERACTION WITH CHOLECYSTOKININ RECEPTORS IN A NEUROENDOCRINE CELL LINE, HUMAN SMALL-CELL LUNG CARCINOMA. THESE COMPOUNDS, MORE CLOSELY RESEMBLING NATURALLY OCCURRINGNEUROPEPTIDES, SHOULD CROSS-REACT LESS WITH OTHER CENTRAL NERVOUS SYSTEM RECEPTORS, RESULTING IN FEWER UNDESIRABLE SIDE EFFECTS. POTENT COMPOUNDS IDENTIFIED IN THE CELL ASSAYWILL BE FURTHER EVALUATED IN PHARMACOLOGICAL PRECLINICAL STUDIES IN THE PHASE II RESEARCH.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government