BOMBESIN ANTAGONISTS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 18994
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1992
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
125 Michigan Avenue Ne, Washington, DC, 20017
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Martha Knight
 (800) 966-3384
Business Contact
Phone: () -
Research Institution
N/A
Abstract
RECENT BOMBESIN AND GASTRIN RELEASING PEPTIDE RECEPTOR ANTAGONISTS HAVE BEEN DEMONSTRATED TO B E QUITE POTENT IN INHIBITING THE EFFECTS OF BOMBESIN IN PANCREATIC ACINAR CELLS, BRAIN MEMBRANES, SWISS 3T3 FIBROBLASTS, AND HUMAN SMALL CELL LUNG CARCINOMA (SCLC). HOWEVER, THESE ANTAGONISTS DO NOT DISPLAY COMPARABLE HIGH POTENCY IN INHIBITING THE PROLIFERATION OF HUMAN SMALL CELL LUNG CARCINOMA. CERTAIN BOMBESIN ANTAGONISTS DO INHIBIT PROLIFERATION OF CLONAL GROWTH OF SCLC AND HAVE BEEN FOUND TO INHIBIT SCLC TUMOR GROWTH IN VIVO. STUDIES WILL BE CONDUCTED TO DESIGN AND SYNTHESIZE MORE STABLE COMPOUNDS FROM THE INHIBITOR STRUCTURES BY CYCLIZATION AND DESCREASING THEIR SUSCEPTIBILITY TO PROTEOLYTIC DEGRADATION. NOVEL GROUPS WILL BE ADDED TO THE ANTAGONISTS TO INCREASE INTERACTION WITH SCLC RECEPTOR. THE EFFECT ON CLONAL GROWTH OF HUMAN SCLC CELLS WILL BE MEASURED AS AN INDICATOR OF IN VIVO ANTI-TUMOR POTENTIAL.

* Information listed above is at the time of submission. *

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