MEMBRANE BASED PEPTIDE SYNTHESIS

Award Information
Agency:
National Science Foundation
Branch:
N/A
Amount:
$46,500.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
N/A
Agency Tracking Number:
14379
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Peptides International Inc
10101 Linn Station Rd, Louisville, KY, 40223
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 Deanne Benovitz
 Sr. Technical Representative
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
MICROPOROUS MEMBRANES ARE USED IN A VARIETY OF SUPPORT FUNCTIONS, RANGING FROM PARTICLE FILTRATION TO AFFINITY LIGAND MEDIA. THEY PROVIDE A LARGE EXTENDED SURFACE THAT ISRAPIDLY ACCESSIBLE BY VIRTUE OF CONVECTIVE FLOW THROUGH THEIR PORE STRUCTURE. SUCH CONVECTIVE FLOW OFFERS THE POSSIBILITY OF MUCH MORE RAPID REACTIONS OR COMPLEXATION WHEN COMPARED TO PROCESSES LIMITED BY DIFFUSION. IN THE PREPARATION OF SYNTHETIC PEPTIDES THE USE OF MICROPOROUS MEDIA IN BEAD FORM IS WELL ESTABLISHED. HOWEVER, DELIVERY OF REAGENTS, REMOVAL OF BY-PRODUCTS, AND REACTIVATION OF INTERMEDIATES ARE ALL DIFFUSION DEPENDENT WHEN SUCH MEDIA ARE USED. FOR CERTAIN APPLICATIONS THIS DIFFUSIVE CONTROL MITIGATES BOTH PRODUCT PURITY AND SCALE-UP POTENTIAL. WE PROPOSE TO STUDY THE FEASIBILITY OF MEMBRANE BASED PEPTIDE SYNTHESIS (MBPS) BY A CAREFULLY CONTROLLED SERIES OF MODEL PEPTIDE PREPARATION ON SEVERAL FUNCTIONALIZED MEMBRANE SUPPORTS. DURING PHASE I WE WILL DETERMINE THE MOST APPROPRIATE LINKAGE CHEMISTRIES, SELECT APPROPRIATE SOLVENT(S) AND SURVEY THE MOST PROMISING MICROPOROUS MEMBRANE MATERIALS FOR THEIR UTILITY. THIS PHASE WILL CULMINATE IN THE DEMONSTRATED SYNTHESIS OF A PEPTIDE ON THE MEMBRANE SUPPORT AND DETERMINATION OF ITS STRUCTURAL INTEGRITY.

* information listed above is at the time of submission.

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