DEVELOPMENT OF A NONSURFACTANT FORMULATION FOR INDUCING AGENTS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$318,778.00
Award Year:
1992
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
13899
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Pharmatec Inc.
Po Box 730, Alachua, FL, 32615
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Wesley R Anderson
(904) 462-1210
Business Contact:
() -
Research Institution:
n/a
Abstract
ADVERSE REACTIONS HAVE BEEN REPORTED TO OCCUR AFTER ADMINISTRATION OF COMPOUNDS SOLUBILIZED IN AQUEOUS VEHICLES. THESE SIDE EFFECTS MAY BE REDUCED OR ELIMINATED BY COMBINING THE PRIMARY INDUCING AGENT, ALFAXALONE, WITH CYCLODEXTRINS, WHICH HAVE BEEN SHOWN TO IMPROVE SOLUBILITY AND EFFICACY OF OTHER STEROIDS. PRELIMINARY STUDIES IN A RAT MODEL SHOW PROMISE FOR THIS COMBINATION. SUCCESSFUL DEVELOPMENT OF THIS TECHNIQUE WILL PROVIDE A SAFE ALTERNATIVE FOR A NONSURFACTANT FORMULATION FOR THE INDUCINGAGENT, REDUCING TOXIC SIDE EFFECTS AND ALLOWING SAFE AND RELIABLE ANESTHESIA.

* information listed above is at the time of submission.

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