AN ULTRASONIC NEURAL STIMULATOR

AN ULTRASONIC NEURAL STIMULATOR

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R41NS042978-01
Agency Tracking Number: NS042978
Amount: $100,000.00
Phase: Phase I
Program: STTR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
PHOENIX BIOTECH, INC., 6051 E CACTUS WREN RD, PARADISE VALLEY, AZ, 85283
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 BRUCE TOWE
 (480) 965-4116
 BRUCE.TOWE@ASU.EDU
Business Contact
 WILLIAM CRISP
Phone: (480) 348-0413
Email: BOGIEBEAR2@HOME.COM
Research Institution
 ARIZONA STATE UNIVERSITY
 ASU
TEMPE, AZ, 85287
 Nonprofit college or university
Abstract
A remarkable and unexpected interaction effect between high frequency ultrasound energy and bioelectrically excitable tissue will be employed to the development of a line of advanced microstimulators for medical neurogenic applications An excised nerve preparation as well as hippocampal tissue slices of the rat brain will be used as physiologic models for further study of the ultrasound interactions with natural and applied bioelectric currents. The limits of ultrasound effectiveness in this application, some preliminary evaluations of its safety, and exploration of different methods of applying the ultrasound to neural tissue will be conducted. Micro-sized ultrasound transducers will be fabricated using photographic techniques and submillimeter diameter lithium niobate crystals in an effort to characterize the ultimate limits of its miniaturization and potential for implantation. This work will serve to underpin a new approach to neuro-electric stimulation that uses ultrasound energy to substantially reduce the current levels required to stimulate nerves in the body and possibly open up new applications of neural stimulation.

* Information listed above is at the time of submission. *

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