SPECTROSCOPY AND THREE-DIMENSIONAL HYDROGEN, SODIUM, AND PHO

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$481,592.00
Award Year:
1986
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
3316
Agency Tracking Number:
3316
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3401 Market St. #320, Philadelphia, PA, 19104
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Roger Wheatley
Principal Investigator
(215) 387-4429
Business Contact:
() -
Research Institute:
n/a
Abstract
THE THREE-DIMENSIONAL VISUALIZATION OF ORGANS AND TISSUES BY PROTON NUCLEAR MAGNETIC RESONANCE HAS BEEN POSSIBLE FOR SEVERAL YEARS, AND NOW ACTIVITY IS DIRECTED TOWARDS VISUALIZATION OF OTHER NUCLEI, SUCH AS PHOSPHORUS AND SODIUM AND CONSTITUENTS OF HYDROGEN-CONTAINING MOLECULES SUCH AS LACTATE WHICH ARE NOT ONLY LESS ABUNDANT IN TISSUE BUT SUFFER FROM A LOWER INTRINSIC NMR SENSITIVITY. USING SPECTROSCOPIC TECHNIQUES SUCCESSFULLY DEVELOPED FOR THE IN VIVO OBSERVATION OF 31P AND HIGH RESOLUTION 1H, PHOSPHO-ENERGETICS, INC. PROPOSES TO COMBINE THIS WITH 1H IMAGING TECHNIQUES TO FURTHER EVALUATE 31P AND 23NA IMAGING IN PHANTOMS AND ANIMALS WITH THE EVENTUAL GOAL OF COMBINING THIS INTO ITS NEONATAL ORGAN ANALYZER UNDER DEVELOPMENT. IN ADDITION, SIMULTANEOUS ACQUISITION OF SPECTROSCOPIC AND IMAGING DATA FROM TWO OR MORE NUCLEI WOULD NOT ONLY SAVE TIME OVER SEQUENTIAL METHODS BUT WOULD HELP EVALUATE THE DIFFERENT TEMPORAL RELATIONSHIPS BETWEEN NUCLEI SUCH AS HYDROGEN, SODIUM, AND PHOSPHORUS.

* information listed above is at the time of submission.

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