THIS PROPOSAL DESCRIBES A NEW METHOD FOR STABILIZING THE ENERGY STATE OF THE BRAIN THAT IS THREATENED BY HYPOXIC DISTRESS DUE TO FAILURE OF ADEQUATE O2 DELIVERY.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,484.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
3298
Agency Tracking Number:
3298
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3401 Market St., Rm. 320, Philadelphia, PA, 19104
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ROGER WHEATLEY
PRINCIPAL INVESTIGATOR
(215) 387-4429
Business Contact:
() -
Research Institution:
n/a
Abstract
THIS PROPOSAL DESCRIBES A NEW METHOD FOR STABILIZING THE ENERGY STATE OF THE BRAIN THAT IS THREATENED BY HYPOXIC DISTRESS DUE TO FAILURE OF ADEQUATE O2 DELIVERY. THE ENERGY STATE OF THE BRAIN IS EVALUATED BY 31P NMR EVERY 2 TO 4 MINUTES AND THE RATIO OF PHOSPHOCREATINE (PCR) TO INORGANIC PHOSPHATE (PI) OR TO ADENOSINE TRIPHOSPHATE (ATP) IS EMPLOYED AS A QUANTITATIVE MEASURE OF THIS ENERGY STATE. MODEL STUDIES SHOW THAT VALUES FOR PCR/PI ABOVE 1.0 AFFORD STABLE FUNCTION OF BRAIN (AND HEART) METABOLISM AND VALUES BELOW 1.0 APPEAR TO BE INSUFFICIENT FOR LONG-TERM ORGAN SURVIVAL. VARIATION OF THE OXYGEN DELIVERED TO THE TISSUES (FIO2) WILL CONTROL THIS RATIO PARTICULARLY IN CASES OF INSUFFICIENT LUNG FUNCTION AS IN RESPIRATORY DISTRESSED NEONATES, BUT NOT LIMITED THERETO. THE SPECIFIC PROPOSAL FOR PHASE I INVOLVES THE TESTING OF THE MANUAL CONTROL OF FIO2 IN RESPONSE TO THE NEED FOR HEART OR BRAIN PCR/PI VALUES THAT ARE ABOVE 1.0, FIRST IN ANIMAL MODELS, SECONDARILY (PHASES I AND II) IN RESPIRATORY DISTRESSED NEONATES AND, AS LARGER MAGNETS BECOME AVAILABLE, IN ADULTS WHO REQUIRE OXYGEN THERAPY. SERVO CONTROL OF THE BRAIN OR HEART ENERGY STATE IS DESCRIBED AND REPRESENTS THE SECOND PHASE (II) OF DEVELOPMENT THAT AFFORDS AN AUTOMATIC CONTROL AND PRESENTATION OF EVEN MOMENTARY LOSS OF ORGAN ENERGY STATES IN PATIENTS WITH DISEASES OF O2 DELIVERY TO TISSUE.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government