TEA-CO2 DEBRIDEMENT OF BURN ESCHAR (7130-260)

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
16615
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Physical Sciences, Inc
20 New England Business Center, Andover, MA, 01810
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Rosen, David I
Principal Investigator
(508) 689-0003
Business Contact:
1 R43 GM43676-01A1
() -
Research Institution:
n/a
Abstract
THE OBJECTIVE OF THIS PROJECT IS TO INVESTIGATE THE FEASIBILITY OF UTILIZING COMMERCIALLY AVAILABLE REPETITIVELY-PULSED CO2 TEA LASER TECHNOLOGY FOR THE PRECISE, CONTROLLED DEBRIDEMENT OF BURN ESCHAR IN THE TREATMENT OF FULL THICKNESS DERMAL BURNS. PRELIMINARY INVESTIGATIONS SUGGEST THAT THE NARROW ZONE OF THERMALLY-COAGULATED TISSUE LEFT BY THE CO2 TEA LASER COULD PROVIDE NEARLY OPTIMUM CONDITIONS FOR SKIN GRAFTING. PHASE I STUDIES WILL INVOLVE ANIMAL EXPERIMENTS TO ASSESS THE EFFECTIVENESS OF THE TEA LASER FOR DEBRIDING ESCHAR FROM CONTROLLED FULL THICKNESS DERMAL BURNS. QUANTITATIVE MEASUREMENTS WILL BE MADE OF THE ABLATION RATE AS WELL AS THE EXTENT OF RESIDUAL THERMAL DAMAGE FOUND IN THE UNDERLYING TISSUE. ALSO INVESTIGATED WILL BE THE UTILITY OF USING FAST, REAL-TIME PHOTOTHERMAL RADIOMETRY AS FEEDBACK GUIDANCE FOR DETERMINING WHEN THE NECROTIC/VIABLE TISSUE INTERFACE HAS BEEN REACHED. IF SUCCESSFUL, THIS RESEARCH WOULD LEAD TO THE DEVELOPMENT OF A SIGNIFICANTLY IMPROVED TECHNIQUE FOR THE RAPID, PRECISE, AND CONTROLLED DEBRIDEMENT OF BURN ESCHAR WITH MINIMAL BLOOD LOSS AND DAMAGE TO UNDERLYING VIABLE TISSUE. THE OBJECTIVE IS TO INCREASE THE SUCCESS WITH WHICH DERMAL AND EPIDERMAL TISSUE CAN BE GRAFTED THEREBY LOWERING MORBIDITY AND MORTALITY AND IMPROVING COSMETIC APPEARANCE.

* information listed above is at the time of submission.

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